• Product name

  • Description

    Rabbit polyclonal to PLA2R
  • Host species

  • Tested applications

    Suitable for: IHC-Fr, WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Rabbit, Cow
  • Immunogen

    Synthetic peptide derived from the C terminal domain of human PLA2R

  • General notes

    We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result, we are pleased to offer this antibody in a purified format as of 23rd June 2017. The following lots are still unpurified and still in stock as of 23rd June 2017 - GR3173938-1, GR3173938-3, GR3173938-4, GR3173938-5, GR306201-4, GR306201-5, GR3173938-2, GR306201-3, GR306201-2, GR281777-4. Lot numbers other than GR3173938-1, GR3173938-3, GR3173938-4, GR3173938-5, GR306201-4, GR306201-5, GR3173938-2, GR306201-3, GR306201-2, GR281777-4 will be purified. Please note that the dilutions may need to be adjusted accordingly. Purified antibodies have the advantage of being enriched for the fraction of immunoglobulin that specifically reacts with the target antigen and for having a reduction of serum proteins.



Our Abpromise guarantee covers the use of ab80054 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-Fr 1/100 - 1/1000.
WB 1/500 - 1/5000. Predicted molecular weight: 169 kDa.Can be blocked with PLA2R peptide (ab176432).


  • Function

    Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B.
  • Tissue specificity

    Present in lung macrophage (at protein level). Highly expressed in kidney. Also expressed in pancreas, amnion, choriodecidua and placenta. Isoform 2 is expressed at much lower level.
  • Sequence similarities

    Contains 8 C-type lectin domains.
    Contains 1 fibronectin type-II domain.
    Contains 1 ricin B-type lectin domain.
  • Domain

    C-type lectin domains 3-5 mediate the interaction with phospholipase PLA2G1B.
    The endocytosis signal probably mediates endocytosis via clathrin-coated pits.
  • Post-translational

    The secretory phospholipase A2 receptor form may be produced by the action of metalloproteinases. It contains all extracellular domains and only lacks transmembrane and cytosolic regions. It is however unclear whether this form is produced by proteolytic cleavage as suggested by some experiments, or by alternative splicing, as in the case of isoform 2 that shares all characteristics of secretory phospholipase A2 receptor form.
  • Cellular localization

    Secreted and Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • 180 kDa secretory phospholipase A2 receptor antibody
    • C-type lectin domain family 13 member C antibody
    • CLEC13C antibody
    • M type receptor antibody
    • M-type receptor antibody
    • Phospholipase A2 receptor 1 antibody
    • PLA2 R antibody
    • PLA2-R antibody
    • PLA2G1R antibody
    • PLA2IR antibody
    • PLA2R antibody
    • PLA2R_HUMAN antibody
    • PLA2R1 antibody
    • Soluble PLA2-R antibody
    • Soluble PLA2R antibody
    • Soluble secretory phospholipase A2 receptor antibody
    see all


  • ab50084 staining PLA2R in Human renal tissue sections by Immunohistochemistry (IHC-Fr - frozen sections). Tissue was fixed with MTM. Samples were incubated with primary antibody (1/100 in BSA) for 2 hours at 25°C.

    See Abreview


This product has been referenced in:

  • Ramachandran R  et al. Membranous Nephropathy With Light Chain Restricted Deposits. Nephrology (Carlton) N/A:N/A (2018). Read more (PubMed: 29633425) »
  • Ramachandran R  et al. PLA2R antibodies, glomerular PLA2R deposits and variations in PLA2R1 and HLA-DQA1 genes in primary membranous nephropathy in South Asians. Nephrol Dial Transplant 31:1486-93 (2016). Read more (PubMed: 26673907) »
See all 3 Publications for this product

Customer reviews and Q&As

1-6 of 6 Abreviews or Q&A

Immunohistochemistry (Frozen sections)
Human Tissue sections (Renal biopsy (fresh frozen))
Renal biopsy (fresh frozen)

Dr. Ashwani Kumar Verma

Verified customer

Submitted Aug 06 2015


Thank you for contacting us. Kidney would be a good control for this product. Please let me know if you have any further questions.

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Thank you for contacting us and your interest in our products.

Unfortunately, we do not currently have any antibodies directed against PLA2R which have shown to detect the protein in mouse samples. I have checked the immunogen used to raise the two antibodies we have against this target (ab80054 and ab99466). Both unfortunately share very low sequence homology with the mouse protein, we would therefore not expect the antibodies to cross react.

I am sorry that I could not be of more help in this instance. If you have any further questions, please do not hesitate to ask.

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L'anticorps ab80054 est fourni sous forme non purifié (anti-sérum), sa concentration ne peut donc pas être déterminé. Pour information, la concentration d'anticorps dans unanti-sérum est estimée entre 1 et 10 mg/ml.

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Thank you for your enquiry.

With what specific application does your customer wish to use the antibody? And what species of serum are they working with?

Thanks for the additional information.

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Thank you for contacting us. I can confirm that the immunogen sequences for these two antibodies are different. The immunogen for ab99466 is from an internal domain (amino acid 946 - 957), whereas the immunogen for ab80054 is from a C terminal domain (exact sequence is however proprietary information). I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

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