Key features and details
- Rabbit polyclonal to Plakophilin 2/PKP2
- Suitable for: ICC/IF, IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Plakophilin 2/PKP2 antibody
See all Plakophilin 2/PKP2 primary antibodies
DescriptionRabbit polyclonal to Plakophilin 2/PKP2
Tested applicationsSuitable for: ICC/IF, IHC-Pmore details
Species reactivityReacts with: Human
- ICC: Caco-2 cells. IHC-P: Human heart, testis, liver and prostate tissues.
This product was previously labelled as Plakophilin 2
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab220840 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ICC/IF||Use a concentration of 0.25 - 2 µg/ml.
Fixation/Permeabilization: PFA/Triton X-100.
|IHC-P||1/200 - 1/500.|
FunctionMay play a role in junctional plaques.
Tissue specificityDetected in heart right ventricle (at protein level). Widely expressed. Found at desmosomal plaques in simple and stratified epithelia and in non-epithelial tissues such as myocardium and lymph node follicles. In most stratified epithelia found in the desmosomes of the basal cell layer and seems to be absent from suprabasal strata.
Involvement in diseaseFamilial arrhythmogenic right ventricular dysplasia 9
Sequence similaritiesBelongs to the beta-catenin family.
Contains 8 ARM repeats.
Cellular localizationNucleus. Cell junction > desmosome. Nuclear and associated with desmosomes.
- Information by UniProt
- ARVD 9 antibody
- ARVD9 antibody
- PKP 2 antibody
Immunohistochemical anlysis of paraffin-embedded human heart tissue staining Plakophilin 2/PKP2 with ab220840 at 1/500 dilution.
Immunofluorescent analysis of PFA fixed, triton X-100 permeabilized Caco2 cells labeling Plakophilin 2/PKP2 using ab220840 at 4 μg/ml (green).
Immunohistochemical anlysis of paraffin-embedded human testis tissue staining Plakophilin 2/PKP2 with ab220840 at 1/500 dilution.
Immunohistochemical anlysis of paraffin-embedded human liver tissue staining Plakophilin 2/PKP2 with ab220840 at 1/500 dilution.
Immunohistochemical anlysis of paraffin-embedded human prostate tissue staining Plakophilin 2/PKP2 with ab220840 at 1/500 dilution.
ab220840 has not yet been referenced specifically in any publications.