Overview

  • Product name

    Anti-PLCG 2 (phospho Y1217) antibody
    See all PLCG 2 primary antibodies
  • Description

    Rabbit polyclonal to PLCG 2 (phospho Y1217)
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide within Human PLCG 2 (internal sequence) (phospho Y1217). The exact sequence is proprietary. Conjugated to a protein carrier.
    Database link: P16885

  • Positive control

    • WB: Pervanadate treated Raji whole cell extract.

Properties

Applications

Our Abpromise guarantee covers the use of ab227053 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 148 kDa.

Target

  • Function

    The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.
  • Sequence similarities

    Contains 1 C2 domain.
    Contains 1 PH domain.
    Contains 1 PI-PLC X-box domain.
    Contains 1 PI-PLC Y-box domain.
    Contains 2 SH2 domains.
    Contains 1 SH3 domain.
  • Post-translational
    modifications

    Phosphorylated on tyrosine residues; upon ligand-induced activation of a variety of growth factor receptors and immune system receptors. Increases phospholipase activity.
  • Information by UniProt
  • Database links

  • Alternative names

    • 1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase gamma 2 antibody
    • 1-phosphatidylinositol-4 antibody
    • 5-bisphosphate phosphodiesterase gamma-2 antibody
    • EC 3.1.4.11 antibody
    • Phosphoinositide phospholipase C antibody
    • Phosphoinositide phospholipase C-gamma-2 antibody
    • Phospholipase C gamma 2 antibody
    • Phospholipase C, gamma 2 (phosphatidylinositol specific) antibody
    • Phospholipase C-gamma-2 antibody
    • Phospholipase C-IV antibody
    • PLC 2 antibody
    • PLC gamma 2 antibody
    • PLC IV antibody
    • PLC-gamma-2 antibody
    • PLC-IV antibody
    • Plcg2 antibody
    • PLCG2_HUMAN antibody
    see all

Images

  • All lanes : Anti-PLCG 2 (phospho Y1217) antibody (ab227053) at 1/1000 dilution

    Lane 1 : Raji (human Burkitt's lymphoma cell line) whole cell extract
    Lane 2 : Raji (human Burkitt's lymphoma cell line) treated with 1 mM pervanadate for 30 minutes, whole cell extract

    Lysates/proteins at 10 µg per lane.

    Secondary
    All lanes : HRP-conjugated anti-rabbit IgG antibody

    Developed using the ECL technique.

    Predicted band size: 148 kDa



    7.5% SDS-PAGE

References

ab227053 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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