Overview

  • Product name

  • Description

    Rabbit polyclonal to PLCL1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Synthetic peptide within Human PLCL1 aa 34-299. The exact sequence is proprietary. NM_006226
    Database link: Q15111

  • Positive control

    • Human heart tissue

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 10% Glycerol, 1.79% Tris glycine
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab190225 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 123 kDa.
IHC-P Use a concentration of 10 µg/ml.

Target

  • Function

    Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as a inhibitor of PPP1C.
  • Tissue specificity

    Expressed in a variety of fetal and adult organs including brain, lung and kidney. Its expression was greatly reduced in small and non-small cell lung carcinoma. Isoform 1 is predominantly expressed in brain.
  • Sequence similarities

    Contains 1 C2 domain.
    Contains 1 PH domain.
    Contains 1 PI-PLC X-box domain.
    Contains 1 PI-PLC Y-box domain.
  • Post-translational
    modifications

    Phosphorylated by the catalytic subunit of PKA. Phosphorylation of Thr-93 resulted in dissociation of PPP1C from PRIP1.
  • Cellular localization

    Cytoplasm.
  • Information by UniProt
  • Database links

  • Alternative names

    • Inactive phospholipase C-like protein 1 antibody
    • Inactive protein 1 antibody
    • Phospholipase C deleted in lung carcinoma antibody
    • Phospholipase C epsilon antibody
    • Phospholipase C like 1 antibody
    • Phospholipase C related but catalytically inactive protein antibody
    • Phospholipase C related, but catalytically inactive protein antibody
    • Phospholipase C-deleted in lung carcinoma antibody
    • Phospholipase C-related but catalytically inactive protein antibody
    • Phospholipase C-related catalytically antibody
    • PLC-L1 antibody
    • PLCE antibody
    • PLCL antibody
    • PLCL1 antibody
    • PLCL1_HUMAN antibody
    • PLDL1 antibody
    • PRIP antibody
    see all

Images

  • Immunohistochemical analysis of formalin fixed, paraffin embedded Human heart labeling PLCL1 with ab190225 at 10 µg/ml.

References

ab190225 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab190225.
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