Key features and details
- Rabbit polyclonal to PLD6
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-PLD6 antibody
See all PLD6 primary antibodies
DescriptionRabbit polyclonal to PLD6
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
- Human testis tissue.
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Storage bufferpH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab151059 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/10 - 1/20. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.|
FunctionCardiolipin hydrolase present at the mitochondrial outer membrane required both for mitochondrial fusion and piRNA metabolic process. Acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting mitochondrial fusion. The production of phosphatidate also regulates the piRNA metabolic process by promoting recruitment and/or activation of components of the meiotic nuage, also named P granule, a critical step for primary biogenesis of piRNAs. Required during spermatogenesis to repress transposable elements and prevent their mobilization via its role in the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons.
Tissue specificityWidely expressed. Expression is not limites to testis and ovary.
Sequence similaritiesBelongs to the phospholipase D family. MitoPLD/Zucchini subfamily.
Contains 1 PLD phosphodiesterase domain.
DomainIn contrast to other members of the phospholipase D family, contains only one PLD phosphodiesterase domain, suggesting that it has a single half-catalytic and requires homodimerization to form a complete active site (PubMed:17028579).
Cellular localizationMitochondrion outer membrane.
- Information by UniProt
- Choline phosphatase 6 antibody
- Mitochondrial cardiolipin hydrolase antibody
- Mitochondrial phospholipase antibody
ab151059 has not yet been referenced specifically in any publications.