Overview

  • Product name

  • Description

    Rabbit polyclonal to Plexin A1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Rat
    Predicted to work with: Human
  • Immunogen

    Synthetic peptide within Human Plexin A1 aa 930-980 conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
    Database link: Q9UIW2

  • Positive control

    • IHC-P: Rat brain tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab217634 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500.

Target

  • Relevance

    Function: Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Tissue specificity: Detected in fetal brain, lung, liver and kidney. Similarity: Belongs to the plexin family. Contains 4 IPT/TIG domains. Contains 1 Sema domain.
  • Cellular localization

    Cell Membrane
  • Database links

  • Alternative names

    • NOV antibody
    • NOV/plexin A1 protein antibody
    • NOVP antibody
    • Plexin-A1 antibody
    • Plexin1 antibody
    • PlexinA1 antibody
    • PLXA1_HUMAN antibody
    • PLXN1 antibody
    • Plxna1 antibody
    • PLXNA1 protein antibody
    • Semaphorin receptor NOV antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed and paraffin-embedded rat brain tissue labeling Plexin A1 with ab217634 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

References

This product has been referenced in:

  • Wang WW  et al. MicroRNA-134 prevents the progression of esophageal squamous cell carcinoma via the PLXNA1-mediated MAPK signalling pathway. EBioMedicine 46:66-78 (2019). Read more (PubMed: 31383552) »
See 1 Publication for this product

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