Key features and details
- Rabbit polyclonal to PLGF
- Suitable for: WB, ELISA
- Reacts with: Human
- Isotype: IgG
Product nameAnti-PLGF antibody
See all PLGF primary antibodies
DescriptionRabbit polyclonal to PLGF
Tested applicationsSuitable for: WB, ELISAmore details
Species reactivityReacts with: Human
Recombinant fragment corresponding to Human PLGF aa 19-170.
Database link: P49763-3
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle.
Storage bufferpH: 7.40
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab11938 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 2 - 5 µg/ml. Predicted molecular weight: 25 kDa.
Detects 25-50 ng/lane of recombinant human PlGF1 and PlGF2 under reducing and non-reducing conditions.
|ELISA||Use a concentration of 1 - 5 µg/ml. Allows the detection of 1.0- 2.5 ng/well of recombinant human PlGF1 and PlGF2.|
FunctionGrowth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner.
Tissue specificityWhile the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas.
Sequence similaritiesBelongs to the PDGF/VEGF growth factor family.
DomainIsoform PlGF-2 contains a basic insert which acts as a cell retention signal.
Cellular localizationSecreted. The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin.
- Information by UniProt
- D12S1900 antibody
- Pgf antibody
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ab11938 has been referenced in 1 publication.
- Wang Z et al. ß-elemene enhances anticancer bone neoplasms efficacy of paclitaxel through regulation of GPR124 in bone neoplasms cells. Oncol Lett 16:2143-2150 (2018). PubMed: 30008912