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Anti-PLOD3 antibody (ab128698)

  • Datasheet
  • SDS
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PLOD3 antibody (ab128698)

    Key features and details

    • Rabbit polyclonal to PLOD3
    • Suitable for: IHC-P
    • Reacts with: Human
    • Isotype: IgG

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    Overview

    • Product name

      Anti-PLOD3 antibody
      See all PLOD3 primary antibodies
    • Description

      Rabbit polyclonal to PLOD3
    • Host species

      Rabbit
    • Tested Applications & Species

      Application Species
      IHC-P
      Human
      See all applications and species data
    • Immunogen

      Recombinant fragment, corresponding to amino acids 254-508 of Human PLOD3 (BC011674).

    • Positive control

      • human fetal kidney lysate for western blot, formalin-fixed paraffin-embedded human fetal small intestine for ICH-P

    Properties

    • Form

      Lyophilized:Reconstitute with 200ul distilled sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary.
    • Storage instructions

      Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
    • Storage buffer

      Preservative: 0.02% Sodium azide
      Constituent: 1% BSA
    • Concentration information loading...
    • Purity

      Immunogen affinity purified
    • Clonality

      Polyclonal
    • Isotype

      IgG

    Associated products

    • Compatible Secondaries

      • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
      • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    • Isotype control

      • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab128698 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Guaranteed

    Tested applications are guaranteed to work and covered by our Abpromise guarantee.

    Predicted

    Predicted to work for this combination of applications and species but not guaranteed.

    Incompatible

    Does not work for this combination of applications and species.

    Application Species
    IHC-P
    Human
    All applications
    Mouse
    Rat
    Application Abreviews Notes
    IHC-P
    1/100 - 1/500.
    Notes
    IHC-P
    1/100 - 1/500.

    Target

    • Function

      Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.
    • Involvement in disease

      Defects in PLOD3 are the cause of lysyl hydroxylase 3 deficiency (LH3 deficiency) [MIM:612394]; also known as bone fragility with contractures arterial rupture and deafness. LH3 deficiency is a connective tissue disorder. The syndrome is characterized by congenital malformations severely affecting many tissues and organs and revealing features of several collagen disorders, most of them involving COL2A1 (type II collagen). The findings suggest that the failure of lysyl hydroxylation and hydroxylysyl carbohydrate addition, which affects many collagens, is the molecular basis of this syndrome.
    • Sequence similarities

      Contains 1 Fe2OG dioxygenase domain.
    • Cellular localization

      Rough endoplasmic reticulum membrane.
    • Target information above from: UniProt accession O60568 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 8985 Human
      • Entrez Gene: 26433 Mouse
      • Entrez Gene: 288583 Rat
      • Omim: 603066 Human
      • SwissProt: O60568 Human
      • SwissProt: Q9R0E1 Mouse
      • SwissProt: Q5U367 Rat
      • Unigene: 153357 Human
      • Unigene: 251003 Mouse
      • Unigene: 90152 Rat
      see all
    • Alternative names

      • 2-oxoglutarate 5-dioxygenase 3 antibody
      • bone protein I antibody
      • BP-I antibody
      • LH3 antibody
      • Lysine hydroxylase 3 antibody
      • Lysyl hydroxylase 3 antibody
      • Plod3 antibody
      • PLOD3_HUMAN antibody
      • Procollagen lysine,2 oxoglutarate 5 dioxygenase 3 precursor antibody
      • Procollagen-lysine antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PLOD3 antibody (ab128698)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PLOD3 antibody (ab128698)
      ab128698, at a dilution of 1/100, staining PLOD3 in Formalin-fixed, Paraffin-embedded human fetal small intestine by Immunohistochemistry

    Protocols

    • Immunohistochemistry protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
    • SDS
  • References (2)

    Publishing research using ab128698? Please let us know so that we can cite the reference in this datasheet.

    ab128698 has been referenced in 2 publications.

    • Li H  et al. Overexpression of LH3 reduces the incidence of hypertensive intracerebral hemorrhage in mice. J Cereb Blood Flow Metab 39:547-561 (2019). PubMed: 30516406
    • Shao S  et al. Lysyl Hydroxylase Inhibition by Minoxidil Blocks Collagen Deposition and Prevents Pulmonary Fibrosis via TGF-ß1/Smad3 Signaling Pathway. Med Sci Monit 24:8592-8601 (2018). PubMed: 30481795

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