Plumbagin, Anticancer and anti-inflammatory agent (ab145184)

Overview

  • Product name

    Plumbagin, Anticancer and anti-inflammatory agent
  • Description

    Anticancer and anti-inflammatory agent
  • Biological description

    Anticancer and anti-inflammatory agent. Promotes autophagocytosis. Induces G2/M cell cycle arrest and apoptosis. Inhibits Akt/mTOR signaling. Induces PI 5 kinase-dependent- ROS generation. Inhibits NFκB activation. Shows antitumor and immunosuppressive effects in vivo.
  • CAS Number

    481-42-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-Hydroxy-2-methylnaphthalene-1,4-dione
  • Molecular weight

    188.18
  • Molecular formula

    C11H8O3
  • PubChem identifier

    10205
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 50 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=CC(=O)C2=C(C1=O)C=CC=C2O
  • Source

    Plumbago indica

  • Research areas

References

This product has been referenced in:

  • Sagar S  et al. Cytotoxicity and apoptosis induced by a plumbagin derivative in estrogen positive MCF-7 breast cancer cells. Anticancer Agents Med Chem 14:170-80 (2014). Read more (PubMed: 24164046) »
  • Li YC  et al. Plumbagin induces apoptotic and autophagic cell death through inhibition of the PI3K/Akt/mTOR pathway in human non-small cell lung cancer cells. Cancer Lett 344:239-59 (2014). Read more (PubMed: 24280585) »
  • Checker R  et al. Anti-inflammatory effects of plumbagin are mediated by inhibition of NF-kappaB activation in lymphocytes. Int Immunopharmacol 9:949-58 (2009). Read more (PubMed: 19374955) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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