Overview

  • Product name

    PluriSIn 1, SCD1 inhibitor
  • Description

    Selective SCD1 inhibitor
  • Biological description

    Selective stearoyl-CoA desaturase-1 (SCD1) inhibitor. Inhibits oleic acid biosynthesis. Induces apoptosis. Decreases Nanog expression. Selectively eliminates undifferentiated embryonic stem cells. Shows cytotoxic effects.
  • Purity

    > 98%
  • CAS Number

    91396-88-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N'-Phenylpyridine-4-carbohydrazide
  • Molecular weight

    213.24
  • Molecular formula

    C12H11N3O
  • PubChem identifier

    225362
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 50 mM and in DMSO to 75 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC=C(C=C1)NNC(=O)C2=CC=NC=C2
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Zhang L  et al. Inhibition of stearoyl-coA desaturase selectively eliminates tumorigenic Nanog-positive cells: improving the safety of iPS cell transplantation to myocardium. Cell Cycle 13:762-71 (2014). Read more (PubMed: 24394703) »
  • Phillips MI Tumor-free iPS stem cells for heart cells. Cell Cycle 13:1519 (2014). Read more (PubMed: 24755736) »
  • Ben-David U  et al. Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen. Cell Stem Cell 12:167-79 (2013). Read more (PubMed: 23318055) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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