Overview

  • Product name

    (±)-Anatoxin A fumarate, nicotinic agonist
  • Description

    Potent nicotinic agonist
  • Biological description

    Potent nicotinic agonist. Neurotoxic alkaloid produced by the cyanobacterium Anabaena flos-aquae. KI values are 1.25 and 1840 nM for α4β2 and α7 nicotinic receptors in rat brain, respectively.

    Also available in simple stock solutions (ab146699) - add 1 ml of water to get an exact, ready-to-use concentration.
  • Purity

    > 98%
  • CAS Number

    64285-06-9
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Sharples CG  et al. UB-165: a novel nicotinic agonist with subtype selectivity implicates the alpha4beta2* subtype in the modulation of dopamine release from rat striatal synaptosomes. J Neurosci 20:2783-91 (2000). Read more (PubMed: 10751429) »
  • Stolerman IP  et al. Behavioural effects of anatoxin, a potent nicotinic agonist, in rats. Neuropharmacology 31:311-4 (1992). Read more (PubMed: 1630597) »
  • Zhang X  et al. Anatoxin-a a potent ligand for nicotinic cholinergic receptors in rat brain. Eur J Pharmacol 135:457-8 (1987). Read more (PubMed: 3582504) »
See 1 Publication for this product

Customer reviews and Q&As

1-10 of 11 Abreviews or Q&A

Question
Answer

The C4H4O4 needs to be taken into consideration when calculating concentration but it is a solubility aid first and foremost.

Read More

Answer

We have measured the optical rotation of this material (c = 1, methanol) and the result was 0º confirming that this is a racemic mixture; this is consistent for all batches. This confirms a 50:50 mixture.

Read More

Answer

This is a racemic mixture: 50% (+)-Anatoxin A fumarate, 50% (-)-Anatoxin A fumarate and all batches are racemic with the same ratio of (+)-Anatoxin A fumarate and (-)-Anatoxin A fumarate.

The stereocentres are at carbons 1 and 6 on the 9-azabicyclo[4.2.1]nonene ring. In (+)-Anatoxin A fumarate both stereocentres are (R) and in (-)-Anatoxin A fumarate both stereocentres are (S).

Read More

Answer

ab120013 is the racemic mixture. The fumarate salt causes the compound to become water soluble.

Read More

Answer

The molecular weight of ab120013 anatoxin A fumarate is 281.31 and its in the fumarate salt form.

Read More

Answer



La présence de 2 pics a également été observée en HPLC lors de la détermination de la pureté du produit. Le lot de ab120013 que vous avez reçu a passé les controles qualité car malgré la présence d'un second pic, sa pureté est supérieure à 98%.

Read More

Question
Answer

Veuillez trouver ci-joint le chromatogramme HPLC du produit ab120013 (asc-013).


Lecomposé a été solubilisé dans l'eau, la longueur d'onde est de 230nm.

J'espère que ces informations vous seront utiles. N'hésitez pas à nous contacter de nouveau si vous avez d'autres questions.

Read More

Answer

Mon collègue du laboratoire suggère de chauffer légèrement la solution (à 0.5mg/ml)et delapasser au bain à ultrason.

Read More

Question
Answer

Merci pour votre appel et votre patience.

Comme je viens de vous confirmer au téléphone, le laboratoire me confirm d'essayer de passer ce produit au bains aux ultrasons. Il est mieux de ne pas chauffer le produit, car, comme vous avez dit, le composé est assez sensible à la température.

J'espère que ceci va resoudre le problème. Veuillez nous tenir au courant. Merci beaucoup.

Read More

Question
Answer

Thank you for contacting us.

I have contacted the laboratory in regards to this compound and am happy to confirm the following:

Wecan confirm that this compound can be solubilised in Acetonitrile to 1mg per ml. As abcam biochemicals are novel compounds and we have not tested their biological activity in house, we do not currently have any long term storage information for this compound. However, we recommend wherever possible, that you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

Read More

1-10 of 11 Abreviews or Q&A

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up