Overview

  • Product name

    (plusminus)-BAYK8644, L-type Ca2+ channel activator
  • Description

    Potent L-type Ca2+ channel activator
  • Biological description

    Potent L-type Ca2+ channel activator (EC50 = 17.3 nM). Centrally active following systemic administration.
  • Purity

    > 99%
  • CAS Number

    71145-03-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester
  • Molecular weight

    356.30
  • Molecular formula

    C16H15F3N2O4
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Samantaray S  et al. Calcium channel agonist, (+/-)-Bay K8644, causes a transient increase in striatal monoamine oxidase activity in Balb/c mice. Neurosci Lett 342:73-6 (2003). Read more (PubMed: 12727321) »
  • Bourson A  et al. Central and peripheral effects of the dihydropyridine calcium channel activator BAY K 8644 in the rat. Eur J Pharmacol 160:339-47 (1989). Read more (PubMed: 2469593) »
  • Rae GA & Calixto JB Interactions of calcium antagonists and the calcium channel agonist Bay K 8644 on neurotransmission of the mouse isolated vas deferens. Br J Pharmacol 96:333-40 (1989). Read more (PubMed: 2466518) »

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