Product name(±)-Lisofylline, Anti-inflammatory agent
Biological descriptionAnti-inflammatory agent. Active metabolite of pentoxifylline and a potent inhibitor of phosphatidic acid formation (IC50 = 0.6 mM). Decreases lipid peroxidation in vitro and in vivo. Suppresses proinflammatory cytokine expression. Can ameliorate glucose intolerance in vivo.
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 25 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Receptors & Transporters
- Enzyme-Linked Receptors
- Cytokine receptors
This product has been referenced in:
- Chen M et al. Lisofylline, a novel antiinflammatory agent, protects pancreatic beta-cells from proinflammatory cytokine damage by promoting mitochondrial metabolism. Endocrinology 143:2341-8 (2002). Read more (PubMed: 12021199) »
- George CL et al. Effects of lisofylline on hyperoxia-induced lung injury. Am J Physiol 276:L776-85 (1999). Read more (PubMed: 10330034) »
- Rice GC et al. Protection from endotoxic shock in mice by pharmacologic inhibition of phosphatidic acid. Proc Natl Acad Sci U S A 91:3857-61 (1994). Read more (PubMed: 8171002) »