Overview

  • Product name

    (±)-Lisofylline, Anti-inflammatory agent
  • Description

    Anti-inflammatory agent.
  • Biological description

    Anti-inflammatory agent. Active metabolite of pentoxifylline and a potent inhibitor of phosphatidic acid formation (IC50 = 0.6 mM). Decreases lipid peroxidation in vitro and in vivo. Suppresses proinflammatory cytokine expression. Can ameliorate glucose intolerance in vivo.
  • Purity

    > 98%
  • CAS Number

    6493-06-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Chen M  et al. Lisofylline, a novel antiinflammatory agent, protects pancreatic beta-cells from proinflammatory cytokine damage by promoting mitochondrial metabolism. Endocrinology 143:2341-8 (2002). Read more (PubMed: 12021199) »
  • George CL  et al. Effects of lisofylline on hyperoxia-induced lung injury. Am J Physiol 276:L776-85 (1999). Read more (PubMed: 10330034) »
  • Rice GC  et al. Protection from endotoxic shock in mice by pharmacologic inhibition of phosphatidic acid. Proc Natl Acad Sci U S A 91:3857-61 (1994). Read more (PubMed: 8171002) »

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