(±)-Nutlin-3, MDM2 antagonist (ab120646)
Key features and details
- Potent, selective MDM2 antagonist
- CAS Number: 548472-68-0
- Purity: > 98%
- Soluble in DMSO to 100 mM and in ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
(±)-Nutlin-3, MDM2 antagonist -
Description
Potent, selective MDM2 antagonist -
Alternative names
- (±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one
- Nutlin-3
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Purity
> 98% -
CAS Number
548472-68-0 -
Chemical structure
Properties
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Chemical name
(±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one -
Molecular weight
581.49 -
Molecular formula
C30H30Cl2N4O4 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (3)
ab120646 has been referenced in 3 publications.
- Sun Z et al. Silencing Ribosomal Protein L22 Promotes Proliferation and Migration, and Inhibits Apoptosis of Gastric Cancer Cells by Regulating the Murine Double Minute 2-Protein 53 (MDM2-p53) Signaling Pathway. Med Sci Monit 27:e928375 (2021). PubMed: 34050122
- Ghassemifar S & Mendrysa SM MDM2 antagonism by nutlin-3 induces death in human medulloblastoma cells. Neurosci Lett 513:106-10 (2012). PubMed: 22343310
- Shangary S & Wang S Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy. Annu Rev Pharmacol Toxicol 49:223-41 (2009). PubMed: 18834305