Key features and details
- Potent, selective MDM2 antagonist
- CAS Number: 548472-68-0
- Purity: > 98%
- Soluble in DMSO to 100 mM and in ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
Product name(±)-Nutlin-3, MDM2 antagonist
DescriptionPotent, selective MDM2 antagonist
Potent, selective MDM2 antagonist; inhibits the MDM2-p53 interaction (IC50 = 0.09 µM) and activates p53. Antiproliferative agent; induces apoptosis in cancer cells.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120646 has been referenced in 2 publications.
- Ghassemifar S & Mendrysa SM MDM2 antagonism by nutlin-3 induces death in human medulloblastoma cells. Neurosci Lett 513:106-10 (2012). PubMed: 22343310
- Shangary S & Wang S Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy. Annu Rev Pharmacol Toxicol 49:223-41 (2009). PubMed: 18834305