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Signal Transduction Protein Trafficking Chaperones Heat Shock Proteins
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(±)-Palmitoylcarnitine chloride, Protein kinase C (PKC) inhibitor (ab141122)

  • Datasheet
  • SDS
  • COA
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Functional Studies - (±)-Palmitoylcarnitine chloride, Protein kinase C (PKC) inhibitor (ab141122)

    Key features and details

    • Protein kinase C (PKC) inhibitor. Intermediate in lipid metabolism.
    • CAS Number: 6865-14-1
    • Purity: > 98%
    • Soluble in water to 10 mM
    • Form / State: Solid
    • Source: Synthetic

    Overview

    • Product name

      (±)-Palmitoylcarnitine chloride, Protein kinase C (PKC) inhibitor
    • Description

      Protein kinase C (PKC) inhibitor. Intermediate in lipid metabolism.
    • Biological description

      Protein kinase C (PKC) inhibitor. Intermediate in long-chain fatty acid metabolism able to disrupt cell membranes.

      Also available in simple stock solutions (ab146730) - add 1 ml of water to get an exact, ready-to-use concentration.

    • Purity

      > 98%
    • CAS Number

      6865-14-1
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      3-Carboxy-N,N,N-trimethyl-2-[(1-oxohexadecyl)oxy]-1-propanaminium chloride
    • Molecular weight

      436.07
    • Molecular formula

      C23H46ClNO4
    • PubChem identifier

      363417
    • Storage instructions

      Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in water to 10 mM
    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      [Cl-].O=C(CCCCCCCCCCCCCCC)OC(CC(=O)O)C[N+](C)(C)C
    • Source

      Synthetic

    • Research areas

      • Signal Transduction
      • Protein Trafficking
      • Chaperones
      • Heat Shock Proteins
      • Epigenetics and Nuclear Signaling
      • DNA / RNA
      • DNA Synthesis
      • Other
      • Signal Transduction
      • Protein Phosphorylation
      • Ser / Thr Kinases
      • PKC
      • Signal Transduction
      • Metabolism
      • Energy Metabolism
      • Epigenetics and Nuclear Signaling
      • Nuclear Signaling Pathways
      • Nuclear Receptors
      • Orphan Nuclear Receptors
      • Cancer
      • Cell cycle
      • Cell division
      • Cancer
      • Tumor biomarkers
      • Other
      • Cancer
      • Cancer Metabolism
      • Metabolic signaling pathway
      • Metabolism of lipids and lipoproteins
      • Biochemicals
      • Product Range
      • Just Add Water
      • Biochemicals
      • Chemical Type
      • Biochemicals
      • Biochemicals
      • Chemical Type
      • Lipid
      • Biochemicals
      • Pharmacology
      • Enzymes
      • Kinase
      • Protein Kinase C
      • Inhibitors
      • Metabolism
      • Pathways and Processes
      • Metabolic signaling pathways
      • Lipid and lipoprotein metabolism
      • Lipid metabolism
      • Metabolism
      • Pathways and Processes
      • Metabolic signaling pathways
      • Energy transfer pathways
      • Energy Metabolism
      • Biochemicals
      • Pharmacology
      • Signaling
      • Lipid signaling
      • Metabolism

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab141122 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    Functional Studies
    Use at an assay dependent concentration.
    Notes
    Functional Studies
    Use at an assay dependent concentration.

    Images

    • Functional Studies - (±)-Palmitoylcarnitine chloride, Protein kinase C (PKC) inhibitor (ab141122)
      Functional Studies - (±)-Palmitoylcarnitine chloride, Protein kinase C (PKC) inhibitor (ab141122)
      ab59720 staining ZO1 in Caco-2 cells treated with (±)-palmitoylcarnitine chloride (ab141122), by ICC/IF. Membranar ZO1 expression loss correlates with increased concentration of (±)-palmitoylcarnitine chloride, as described in literature.
      The cells were incubated at 37°C for 1 hour in media containing different concentrations of ab141122 ((±)-palmitoylcarnitine chloride) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab59720 (0.5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
    • SDS
    • COA
  • References (0)

    Publishing research using ab141122? Please let us know so that we can cite the reference in this datasheet.

    ab141122 has not yet been referenced specifically in any publications.

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