Overview

  • Product name

    (±)-Palmitoylcarnitine chloride, Protein kinase C (PKC) inhibitor
  • Description

    Protein kinase C (PKC) inhibitor. Intermediate in lipid metabolism.
  • Biological description

    Protein kinase C (PKC) inhibitor. Intermediate in long-chain fatty acid metabolism able to disrupt cell membranes.

    Also available in simple stock solutions (ab146730) - add 1 ml of water to get an exact, ready-to-use concentration.
  • Purity

    > 98%
  • CAS Number

    6865-14-1
  • Chemical structure

    Chemical Structure

Properties

Applications

Our Abpromise guarantee covers the use of ab141122 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Functional Studies Use at an assay dependent concentration.

Images

  • ab59720 staining ZO1 in Caco-2 cells treated with (±)-palmitoylcarnitine chloride (ab141122), by ICC/IF. Membranar ZO1 expression loss correlates with increased concentration of (±)-palmitoylcarnitine chloride, as described in literature.
    The cells were incubated at 37°C for 1 hour in media containing different concentrations of ab141122 ((±)-palmitoylcarnitine chloride) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab59720 (0.5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

References

This product has been referenced in:

  • Nalecz KA  et al. Palmitoylcarnitine regulates estrification of lipids and promotes palmitoylation of GAP-43. FEBS Lett 581:3950-4 (2007). Read more (PubMed: 17662726) »
  • Requero MA  et al. The membrane-perturbing properties of palmitoyl-coenzyme A and palmitoylcarnitine. A comparative study. Biochemistry 34:10400-5 (1995). Read more (PubMed: 7654694) »
  • Nakadate T & Blumberg PM Modulation by palmitoylcarnitine of protein kinase C activation. Cancer Res 47:6537-42 (1987). Read more (PubMed: 3479247) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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