(±)-RK-682, protein tyrosine phosphatase inhibitor (ab144625)

Overview

  • Product name

    (±)-RK-682, protein tyrosine phosphatase inhibitor
  • Description

    Selective and competitive protein tyrosine phosphatase inhibitor
  • Biological description

    Selective and competitive protein tyrosine phosphatase inhibitor. Inhibits dephosphorylation activity of VHR (IC50 = 2 µM) and CD45 (IC50 = 54 µM) in vitro. Inhibits cell cycle progression at G1 phase. Limited cell-permeability.
  • Purity

    > 98%
  • CAS Number

    150627-37-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-Hexadecanoyl-5-hydroxymethyltetronic acid
  • Molecular weight

    368.52
  • Molecular formula

    C21H36O5
  • PubChem identifier

    54678922
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 50 mM and in ethanol to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCCCCCCCCCCCCCCC(=O)C1=C(C(OC1=O)CO)O
  • Source

    Synthetic

References

This product has been referenced in:

  • Sun Y  et al. In vitro reconstruction of tetronate RK-682 biosynthesis. Nat Chem Biol 6:99-101 (2010). Read more (PubMed: 20081823) »
  • Usui T  et al. Design and synthesis of a dimeric derivative of RK-682 with increased inhibitory activity against VHR, a dual-specificity ERK phosphatase: implications for the molecular mechanism of the inhibition. Chem Biol 8:1209-20 (2001). Read more (PubMed: 11755399) »
  • Hamaguchi T  et al. RK-682, a potent inhibitor of tyrosine phosphatase, arrested the mammalian cell cycle progression at G1phase. FEBS Lett 372:54-8 (1995). Read more (PubMed: 7556642) »

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