Product namePLX4720, B-Raf inhibitor
DescriptionPotent B-Raf inhibitor
Biological descriptionPotent B-Raf inhibitor (IC50 values are 6.7, 13 and 160 nM for C-Raf-1Y340D/Y341D, B-RafV600E and B-Rafwild-type respectively). Shows antiproliferative effects. Shows antitumor effects in vivo. Orally active.
Storage instructionsStore at +4°C. The product can be stored for up to 12 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Research Area
- Alzheimer's Disease
- Signal transduction
- Raf kinase
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab141362 has been referenced in 1 publication.
- Li S et al. Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance. Nat Commun 10:1693 (2019). PubMed: 30979895