Overview

  • Product name

    PLX4720, B-Raf inhibitor
  • Description

    Potent B-Raf inhibitor
  • Biological description

    Potent B-Raf inhibitor (IC50 values are 6.7, 13 and 160 nM for C-Raf-1Y340D/Y341D, B-RafV600E and B-Rafwild-type respectively). Shows antiproliferative effects. Shows antitumor effects in vivo. Orally active.
  • Purity

    > 95%
  • CAS Number

    918505-84-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Michaelis M  et al. Association between acquired resistance to PLX4032 (vemurafenib) and ATP-binding cassette transporter expression. BMC Res Notes 7:710 (2014). Read more (PubMed: 25300205) »
  • Eum KH  et al. Differential inhibitory effects of two Raf-targeting drugs, sorafenib and PLX4720, on the growth of multidrug-resistant cells. Mol Cell Biochem 372:65-74 (2013). Read more (PubMed: 22941213) »
  • Shao Y & Aplin AE BH3-only protein silencing contributes to acquired resistance to PLX4720 in human melanoma. Cell Death Differ 19:2029-39 (2012). Read more (PubMed: 22858545) »
  • Oikonomou E  et al. Selective BRAFV600E inhibitor PLX4720, requires TRAIL assistance to overcome oncogenic PIK3CA resistance. PLoS One 6:e21632 (2011). Read more (PubMed: 21738740) »
See 1 Publication for this product

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