Recombinant Anti-PMP22 antibody [EPR7088] (ab126769)


  • Product name

    Anti-PMP22 antibody [EPR7088]
    See all PMP22 primary antibodies
  • Description

    Rabbit monoclonal [EPR7088] to PMP22
  • Host species

  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC/IF,IHC-P or IP
  • Species reactivity

    Reacts with: Rat, Human
  • Immunogen

    Synthetic peptide, corresponding to residues in Human PMP22 (Q01453).

  • Positive control

    • MDA-MB-435, 293T, THP1, and C6 cell lysates.
  • General notes

    Mouse: We have preliminary internal testing data to indicate this antibody may not react with this species. Please contact us for more information.


    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result of this work we are pleased to now offer this antibody in purified format. We are in the process of updating our datasheets. The purified format is designated 'PUR' on our product labels. If you have any questions regarding this update, please contact our Scientific Support team.

    This product is a recombinant rabbit monoclonal antibody.



Our Abpromise guarantee covers the use of ab126769 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Detects a band of approximately 22 kDa (predicted molecular weight: 18 kDa).
  • Application notes
    Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
  • Target

    • Function

      Might be involved in growth regulation, and in myelinization in the peripheral nervous system.
    • Involvement in disease

      Defects in PMP22 are the cause of Charcot-Marie-Tooth disease type 1A (CMT1A) [MIM:118220]; also known as hereditary motor and sensory neuropathy IA. CMT1A is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT1 group are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. CMT1A inheritance is autosomal dominant.
      Defects in PMP22 are a cause of Dejerine-Sottas syndrome (DSS) [MIM:145900]; also known as Dejerine-Sottas neuropathy (DSN) or hereditary motor and sensory neuropathy III (HMSN3). DSS is a severe degenerating neuropathy of the demyelinating Charcot-Marie-Tooth disease category, with onset by age 2 years. DSS is characterized by motor and sensory neuropathy with very slow nerve conduction velocities, increased cerebrospinal fluid protein concentrations, hypertrophic nerve changes, delayed age of walking as well as areflexia. There are both autosomal dominant and autosomal recessive forms of Dejerine-Sottas syndrome.
      Defects in PMP22 are a cause of hereditary neuropathy with liability to pressure palsies (HNPP) [MIM:162500]; an autosomal dominant disorder characterized by transient episodes of decreased perception or peripheral nerve palsies after slight traction, compression or minor traumas.
      Defects in PMP22 are the cause of Charcot-Marie-Tooth disease type 1E (CMT1E) [MIM:118300]; also known as Charcot-Marie-Tooth disease and deafness autosomal dominant. CMT1E is an autosomal dominant form of Charcot-Marie-Tooth disease characterized by the association of sensorineural hearing loss with peripheral demyelinating neuropathy.
      Defects in PMP22 may be a cause of inflammatory demyelinating polyneuropathy (IDP) [MIM:139393]. IDP is a putative autoimmune disorder presenting in an acute (AIDP) or chronic form (CIDP). The acute form is also known as Guillain-Barre syndrome.
    • Sequence similarities

      Belongs to the PMP-22/EMP/MP20 family.
    • Cellular localization

    • Information by UniProt
    • Database links

    • Alternative names

      • CMT1A antibody
      • CMT1E antibody
      • DSS antibody
      • GAS-3 antibody
      • GAS3 antibody
      • Growth Arrest Specific 3 antibody
      • Growth arrest-specific protein 3 antibody
      • HMSNIA antibody
      • HNPP antibody
      • MGC20769 antibody
      • Peripheral myelin protein 22 antibody
      • PMP-22 antibody
      • PMP22 antibody
      • PMP22_HUMAN antibody
      • Sp110 antibody
      • Trembler antibody
      see all


    • All lanes : Anti-PMP22 antibody [EPR7088] (ab126769) at 1/1000 dilution

      Lane 1 : MDA-MB-435 cell lysates
      Lane 2 : 293T cell lysates
      Lane 3 : THP1 cell lysates
      Lane 4 : C6 cell lysates

      Lysates/proteins at 10 µg per lane.

      All lanes : Goat anti-Rabbit HRP at 1/2000 dilution

      Predicted band size: 18 kDa

    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD


    ab126769 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    1-2 of 2 Abreviews or Q&A


    Si vous regardez l'image du western blot sur la fiche technique d’ab126769, la voie 4 a été chargée avec un échantillon de rat. La lignée de cellules C6 est une lignée cellulaire de gliome de rat.

    Nous avons également testés des lysats de tissus de cerveau, de cœur, de reins et de rates provenant du rat en plus d’un lysat cellulaire de PC-12.

    Nous résultats pour les lysats de tissus étaient négatifs tandis que pour la lignée de cellules PC-12 une bande à 22 kDa a été détectée avec une bande supplémentaire de ˜ 50 kDa.

    Read More


    Thank you for your inquiry.
    I am happy to confirm that the immunogen is within the first 100 amino acids of Human PMP22 (Q01453).
    I hope this information is helpful and wish you a good weekend.

    Read More

    For licensing inquiries, please contact

    Sign up