Anti-PNN/DRSP antibody (ab108485)
Key features and details
- Rabbit polyclonal to PNN/DRSP
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-PNN/DRSP antibody
See all PNN/DRSP primary antibodies -
Description
Rabbit polyclonal to PNN/DRSP -
Host species
Rabbit -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant fragment (His-tag) corresponding to PNN/DRSP aa 1-132.
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Positive control
- U2OS cells.
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General notes
Previously labelled as Pinin.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
Constituent: PBS -
Concentration information loading...
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Purity
Affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Target
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Function
Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma. -
Tissue specificity
Expressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, epidermis, esophagus, brain and smooth and skeletal muscle. Expressed strongly in melanoma metastasis lesions and advanced primary tumors. -
Sequence similarities
Belongs to the pinin family. -
Post-translational
modificationsPhosphorylated upon DNA damage, probably by ATM or ATR. -
Cellular localization
Nucleus speckle. Cell junction > desmosome. Cell-cell contact area, predominantly desmosome of intercellular adherens junction. Not a nucleocytoplasmic shuttling protein. - Information by UniProt
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Database links
- Entrez Gene: 5411 Human
- Omim: 603154 Human
- SwissProt: Q9H307 Human
- Unigene: 409965 Human
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Alternative names
- 140 kDa nuclear and cell adhesion-related phosphoprotein antibody
- Desmosome-associated protein antibody
- Domain-rich serine protein antibody
see all
Protocols
Datasheets and documents
References (2)
ab108485 has been referenced in 2 publications.
- Carvalho T et al. Pharmacological inhibition of the spliceosome subunit SF3b triggers exon junction complex-independent nonsense-mediated decay. J Cell Sci 130:1519-1531 (2017). PubMed: 28302904
- Bracken CP et al. Regulation of cyclin D1 RNA stability by SNIP1. Cancer Res 68:7621-8 (2008). PubMed: 18794151