Anti-PNN/DRSP antibody (ab108485)

Submit a review Submit a question References (2)

Key features and details

  • Rabbit polyclonal to PNN/DRSP
  • Reacts with: Human
  • Isotype: IgG

Overview

  • Product name

    Anti-PNN/DRSP antibody
    See all PNN/DRSP primary antibodies

  • Description

    Rabbit polyclonal to PNN/DRSP

  • Host species

    Rabbit

  • Species reactivity

    Reacts with: Human

  • Immunogen

    Recombinant fragment (His-tag) corresponding to PNN/DRSP aa 1-132.

  • Positive control

    • U2OS cells.

  • General notes

    Previously labelled as Pinin. 

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

Target

  • Function

    Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma.

  • Tissue specificity

    Expressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, epidermis, esophagus, brain and smooth and skeletal muscle. Expressed strongly in melanoma metastasis lesions and advanced primary tumors.

  • Sequence similarities

    Belongs to the pinin family.

  • Post-translational
    modifications

    Phosphorylated upon DNA damage, probably by ATM or ATR.

  • Cellular localization

    Nucleus speckle. Cell junction > desmosome. Cell-cell contact area, predominantly desmosome of intercellular adherens junction. Not a nucleocytoplasmic shuttling protein.
  • Information by UniProt

  • Database links

    • Alternative names

      • 140 kDa nuclear and cell adhesion-related phosphoprotein antibody
      • Desmosome-associated protein antibody
      • Domain-rich serine protein antibody
      • DRS antibody
      • DRS protein antibody
      • DRSP antibody
      • Melanoma metastasis clone A protein antibody
      • MEMA antibody
      • Nuclear protein SDK3 antibody
      • Pinin antibody
      • PININ_HUMAN antibody
      • PNN antibody
      • SR like protein antibody
      • SR-like protein antibody
      see all

    References (2)

    Publishing research using ab108485? Please let us know so that we can cite the reference in this datasheet.

    ab108485 has been referenced in 2 publications.

    • Carvalho T  et al. Pharmacological inhibition of the spliceosome subunit SF3b triggers exon junction complex-independent nonsense-mediated decay. J Cell Sci 130:1519-1531 (2017). PubMed: 28302904
    • Bracken CP  et al. Regulation of cyclin D1 RNA stability by SNIP1. Cancer Res 68:7621-8 (2008). PubMed: 18794151

    Customer reviews and Q&As

    Show All Reviews Q&A
    Submit a review Submit a question

    There are currently no Customer reviews or Questions for ab108485.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com