Key features and details
- Rabbit polyclonal to PNN/DRSP
- Reacts with: Human
- Isotype: IgG
Product nameAnti-PNN/DRSP antibody
See all PNN/DRSP primary antibodies
DescriptionRabbit polyclonal to PNN/DRSP
Species reactivityReacts with: Human
Recombinant fragment (His-tag) corresponding to PNN/DRSP aa 1-132.
- U2OS cells.
Previously labelled as Pinin.
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferConstituent: PBS
Concentration information loading...
FunctionTranscriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma.
Tissue specificityExpressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, epidermis, esophagus, brain and smooth and skeletal muscle. Expressed strongly in melanoma metastasis lesions and advanced primary tumors.
Sequence similaritiesBelongs to the pinin family.
modificationsPhosphorylated upon DNA damage, probably by ATM or ATR.
Cellular localizationNucleus speckle. Cell junction > desmosome. Cell-cell contact area, predominantly desmosome of intercellular adherens junction. Not a nucleocytoplasmic shuttling protein.
- Information by UniProt
- 140 kDa nuclear and cell adhesion-related phosphoprotein antibody
- Desmosome-associated protein antibody
- Domain-rich serine protein antibody
ab108485 has been referenced in 2 publications.
- Carvalho T et al. Pharmacological inhibition of the spliceosome subunit SF3b triggers exon junction complex-independent nonsense-mediated decay. J Cell Sci 130:1519-1531 (2017). PubMed: 28302904
- Bracken CP et al. Regulation of cyclin D1 RNA stability by SNIP1. Cancer Res 68:7621-8 (2008). PubMed: 18794151