Key features and details
- Selective α7 nAChR agonist
- CAS Number: 123464-89-1
- Purity: > 99%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Product namePNU 282987, alpha7 nAChR agonist
DescriptionSelective α7 nAChR agonist
Selective α7nAChR agonist. Negligible activity at α1β1γδ and α3β4 receptors. High affinity for rat α7nACh receptors (Ki = 26 nM). Functional antagonist at 5-HT3 receptors (IC50 = 4541 nM).
Chemical nameN-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide hydrochloride
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120558 has been referenced in 5 publications.
- Chang KW et al. PNU282987 alleviates Aß-induced anxiety and depressive-like behaviors through upregulation of a7nAChR by ERK-serotonin receptors pathway. Neurosci Lett 731:135118 (2020). PubMed: 32502508
- Gong M et al. Dysfunction of inflammation-resolving pathways is associated with postoperative cognitive decline in elderly mice. Behav Brain Res 386:112538 (2020). PubMed: 32113876
- Chang KW et al. Activation of a7 nicotinic acetylcholine receptor alleviates Aß1-42-induced neurotoxicity via downregulation of p38 and JNK MAPK signaling pathways. Neurochem Int 120:238-250 (2018). PubMed: 30217465
- Beraldo FH et al. Mechanisms of neuroprotection against ischemic insult by stress-inducible phosphoprotein-1/prion protein complex. J Neurochem 145:68-79 (2018). PubMed: 29265373
- Ibrahim AbdEl Fattah L et al. The Effect of Thymoquinone, a7 Receptor Agonist and a7 Receptor Allosteric Modulator on the Cerebral Cortex in Experimentally Induced Alzheimer's Disease in Relation to MSCs Activation. Int J Stem Cells 9:230-238 (2016). Functional Studies . PubMed: 27572711