Overview

  • Product name

    PNU 74654, Wnt signaling pathway blocker
  • Description

    Wnt signaling pathway blocker
  • Biological description

    Wnt signaling pathway blocker. Inhibits Wnt/β-catenin pathway. Blocks the protein-protein interaction between β-catenin and TCF. Antitumor effects.
  • Purity

    > 98%
  • CAS Number

    113906-27-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-Phenoxybenzoic acid [(5-methyl-2-furanyl)methylene]hydrazide
  • Molecular weight

    320.35
  • Molecular formula

    C19H16N2O3
  • PubChem identifier

    60119583
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 75 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=CC=C(O1)C=NNC(=O)C2=CC=CC=C2OC3=CC=CC=C3
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Durand J  et al. Characterization of differential gene expression in adrenocortical tumors harboring beta-catenin (CTNNB1) mutations. J Clin Endocrinol Metab 96:E1206-11 (2011). Read more (PubMed: 21565795) »
  • Wells JA & McClendon CL Reaching for high-hanging fruit in drug discovery at protein-protein interfaces. Nature 450:1001-9 (2007). Read more (PubMed: 18075579) »
  • Trosset JY  et al. Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening. Proteins 64:60-7 (2006). Read more (PubMed: 16568448) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab144613.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up