Overview

  • Product name

    Podophyllotoxin, microtubule assembly inhibitor
  • Description

    Potent, competitive microtubule assembly inhibitor
  • Alternative names

    • PPT
  • Biological description

    Potent, competitive microtubule assembly inhibitor (IC50 = 5 μM). Prevents the formation of mitotic spindles. Antitumor and keratolytic agent. Active in vivo and in vitro. Cell-permeable derivative, etoposide (ab120277), also available.
  • Purity

    > 90%
  • CAS Number

    518-28-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (5R,5aR,8aR,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one
  • Molecular weight

    414.41
  • Molecular formula

    C22H22O8
  • PubChem identifier

    10607
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Slightly soluble in water
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    COC1=CC(=CC(=C1OC)OC)C2C3C(COC3=O)C(C4=CC5=C(C=C24)OCO5)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Li J  et al. Protective effects and mechanisms of curcumin on podophyllotoxin toxicity in vitro and in vivo. Toxicol Appl Pharmacol 265:190-9 (2012). Read more (PubMed: 23088858) »
  • Prasad V  et al. Podophyllotoxin and nocodazole counter the effect of IKP104 on tubulin decay. J Protein Chem 17:663-8 (1998). Read more (PubMed: 9853681) »
  • Loike JD & Horwitz SB Effects of podophyllotoxin and VP-16-213 on microtubule assembly in vitro and nucleoside transport in HeLa cells. Biochemistry 15:5435-43 (1976). Read more (PubMed: 999818) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab142606.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up