Key features and details
- Rabbit polyclonal to POGZ
- Suitable for: WB, ICC/IF
- Reacts with: Mouse, Human
- Isotype: IgG
Product nameAnti-POGZ antibody
See all POGZ primary antibodies
DescriptionRabbit polyclonal to POGZ
Tested applicationsSuitable for: WB, ICC/IFmore details
Species reactivityReacts with: Mouse, Human
Recombinant fragment corresponding to Human POGZ aa 1-562 (N terminal).
MADTDLFMECEEEELEPWQKISDVIEDSVVEDYNSVDKTTTVSVSQQPVS APVPIAAHASVAGHLSTSTTVSSSGAQNSDSTKKTLVTLIANNNAGNPLV QQGGQPLILTQNPAPGLGTMVTQPVLRPVQVMQNANHVTSSPVASQPIFI TTQGFPVRNVRPVQNAMNQVGIVLNVQQGQTVRPITLVPAPGTQFVKPTV GVPQVFSQMTPVRPGSTMPVRPTTNTFTTVIPATLTIRSTVPQSQSQQTK STPSTSTTPTATQPTSLGQLAVQSPGQSNQTTNPKLAPSFPSPPAVSIAS FVTVKRPGVTGENSNEVAKLVNTLNTIPSLGQSPGPVVVSNNSSAHGSQR TSGPESSMKVTSSIPVFDLQDGGRKICPRCNAQFRVTEALRGHMCYCCPE MVEYQKKGKSLDSEPSVPSAAKPPSPEKTAPVASTPSSTPIPALSPPTKV PEPNENVGDAVQTKLIMLVDDFYYGRDGGKVAQLTNFPKVATSFRCPHCT KRLKNNIRFMNHMKHHVELDQQNGEVDGHTICQHCYRQFSTPFQLQCHLE NVHSPYESTTKC
Database link: Q7Z3K3
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Concentration information loading...
Our Abpromise guarantee covers the use of ab171934 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/1000. Predicted molecular weight: 155 kDa.|
FunctionPlays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms.
Sequence similaritiesContains 9 C2H2-type zinc fingers.
Contains 1 DDE domain.
Contains 1 HTH CENPB-type DNA-binding domain.
Cellular localizationNucleus. Chromosome. Cytoplasm. According to some authors, it is not localized to mitotic chromatin (PubMed:19244240). Recruited to trimethylated 'Lys-9' of histone H3.
- Information by UniProt
- KIAA0461 antibody
- MGC71543 antibody
- Pogo transposable element with ZNF domain antibody
All lanes : Anti-POGZ antibody (ab171934) at 1/1000 dilution
Lane 1 : Crude extract of HeLa cells transfected with control siRNA
Lane 2 : Crude extract of HeLa cells transfected with POGZ siRNA
Predicted band size: 155 kDa
Immunofluorescenct analysis of HeLa cells (chromosome spread preparations) labeling POGZ with ab171934 at 1/500 dilution and stained with Hoechst 33342.
Immunofluorescent analysis of Paraformaldehyde-fixed HeLa cells labeling POGZ with ab171934 at 1/500 dilution and stained with Hoechst 33342.
ab171934 has been referenced in 1 publication.
- Lee HS et al. The chromatin remodeler RSF1 controls centromeric histone modifications to coordinate chromosome segregation. Nat Commun 9:3848 (2018). PubMed: 30242288