Overview

  • Product name

  • Description

    Rabbit polyclonal to POLG2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human POLG2.
    Database link: Q9UHN1

  • Positive control

    • HeLa, HepG2, H9C2 and SP20 whole cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab201100 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 55 kDa.

Target

  • Function

    Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA.
  • Involvement in disease

    Defects in POLG2 are the cause of progressive external ophthalmoplegia with mitochondrial DNA deletions autosomal dominant type 4 (PEOA4) [MIM:610131]. Progressive external ophthalmoplegia is characterized by progressive weakness of ocular muscles and levator muscle of the upper eyelid. In a minority of cases, it is associated with skeletal myopathy, which predominantly involves axial or proximal muscles and which causes abnormal fatigability and even permanent muscle weakness. Ragged-red fibers and atrophy are found on muscle biopsy. A large proportion of chronic ophthalmoplegias are associated with other symptoms, leading to a multisystemic pattern of this disease. Additional symptoms are variable, and may include cataracts, hearing loss, sensory axonal neuropathy, ataxia, depression, hypogonadism, and parkinsonism.
  • Cellular localization

    Mitochondrion.
  • Information by UniProt
  • Database links

  • Alternative names

    • DNA directed DNA polymerase gamma 2 antibody
    • DNA polymerase gamma accessory 55 kDa subunit antibody
    • DNA polymerase subunit gamma 2, mitochondrial antibody
    • DNA polymerase subunit gamma-2 antibody
    • DPOG2_HUMAN antibody
    • HP55 antibody
    • mitochondrial antibody
    • Mitochondrial DNA polymerase accessory subunit antibody
    • Mitochondrial DNA polymerase subunit gamma 2 antibody
    • Mitochondrial polymerase gamma 2 antibody
    • MtPolB antibody
    • OTTMUSP00000003758 antibody
    • p55 antibody
    • PEOA4 antibody
    • POLB antibody
    • PolG beta antibody
    • PolG-beta antibody
    • POLG2 antibody
    • POLGB antibody
    • Polymerase (DNA directed), gamma 2, accessory subunit antibody
    • Polymerase, gamma 2 antibody
    • RP23-247J12.3 antibody
    see all

Images

  • All lanes : Anti-POLG2 antibody (ab201100)

    Lane 1 : A549 whole cell lysate
    Lane 2 : HeLa whole cell lysate
    Lane 3 : H9C2 whole cell lysate
    Lane 4 : SP20 whole cell lysate

    Predicted band size: 55 kDa

References

ab201100 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab201100.
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