Anti-Poliovirus Receptor/PVR antibody (ab233102)
Key features and details
- Rabbit polyclonal to Poliovirus Receptor/PVR
- Suitable for: IHC-P, WB
- Reacts with: Mouse, Human
- Isotype: IgG
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- Ethical standards compliant – production is animal-free
Overview
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Product name
Anti-Poliovirus Receptor/PVR antibody
See all Poliovirus Receptor/PVR primary antibodies -
Description
Rabbit polyclonal to Poliovirus Receptor/PVR -
Host species
Rabbit -
Tested applications
Suitable for: IHC-P, WBmore details -
Species reactivity
Reacts with: Mouse, Human -
Immunogen
Recombinant fragment (His-tag) corresponding to Human Poliovirus Receptor/PVR aa 50-350. Expressed in E.coli.
Database link: P15151-1 -
Positive control
- WB: Recombinant human Poliovirus Receptor/PVR protein; Human liver lysate; Mouse heart lysate. IHC-P: Human breast cancer tissue.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.40
Preservative: 0.011% Proclin 300
Constituents: 55.77% Glycerol (glycerin, glycerine), 44.219% PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
Antigen-specific affinity chromatography followed by Protein A affinity chromatography -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab233102 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
Use a concentration of 5 - 20 µg/ml.
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WB |
Use a concentration of 0.5 - 5 µg/ml. Predicted molecular weight: 45 kDa.
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Notes |
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IHC-P
Use a concentration of 5 - 20 µg/ml. |
WB
Use a concentration of 0.5 - 5 µg/ml. Predicted molecular weight: 45 kDa. |
Target
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Function
Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport. -
Sequence similarities
Belongs to the nectin family.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
Cellular localization
Secreted and Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 5817 Human
- Entrez Gene: 52118 Mouse
- Omim: 173850 Human
- SwissProt: P15151 Human
- SwissProt: Q91WP1 Mouse
- Unigene: 171844 Human
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Alternative names
- CD155 antibody
- CD155 antigen antibody
- FLJ25946 antibody
see all
Images
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Anti-Poliovirus Receptor/PVR antibody (ab233102) + Recombinant human Poliovirus Receptor/PVR protein
Secondary
HRP-Linked Guinea pig anti-Rabbit at 1/2000 dilution
Predicted band size: 45 kDa -
All lanes : Anti-Poliovirus Receptor/PVR antibody (ab233102) at 3 µg
Lane 1 : Human liver lysate
Lane 2 : Mouse heart lysate
Secondary
All lanes : HRP-Linked Guinea pig anti-Rabbit at 1/2000 dilution
Predicted band size: 45 kDa -
Formalin-fixed, paraffin-embedded human breast cancer tissue stained for Poliovirus Receptor/PVR using ab233102 at 10 μg/ml in immunohistochemical analysis. DAB staining.
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab233102 has been referenced in 1 publication.
- Chen B et al. TIGIT Deficiency Protects Mice From DSS-Induced Colitis by Regulating IL-17A-Producing CD4+ Tissue-Resident Memory T Cells. Front Immunol 13:931761 (2022). PubMed: 35844584