Key features and details
- Rabbit polyclonal to Poliovirus Receptor/PVR
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
Product nameAnti-Poliovirus Receptor/PVR antibody
See all Poliovirus Receptor/PVR primary antibodies
DescriptionRabbit polyclonal to Poliovirus Receptor/PVR
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Mouse, Human
Full length protein corresponding to Human Poliovirus Receptor/PVR aa 1-417.
Database link: NP_006496.2
This product was previously labelled as Poliovirus Receptor
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferpH: 7.4
Constituent: 2.68% PBS
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab103630 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/1000. Predicted molecular weight: 45 kDa.|
FunctionMediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.
Sequence similaritiesBelongs to the nectin family.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Cellular localizationSecreted and Cell membrane.
- Information by UniProt
- CD155 antibody
- CD155 antigen antibody
- FLJ25946 antibody
Anti-Poliovirus Receptor/PVR antibody (ab103630) at 1/500 dilution + Mouse stomach tissue lysate at 50 µg
Predicted band size: 45 kDa
All lanes : Anti-Poliovirus Receptor/PVR antibody (ab103630) at 1/500 dilution
Lane 1 : Poliovirus Receptor/PVR transfected 293T cell lysate
Lane 2 : Non-transfected 293T cell lysate
Lysates/proteins at 25 µg per lane.
Predicted band size: 45 kDa
ab103630 has been referenced in 3 publications.
- Zheng Q et al. CD155 contributes to the mesenchymal phenotype of triple-negative breast cancer. Cancer Sci 111:383-394 (2020). PubMed: 31830330
- Zheng Q et al. CD155 knockdown promotes apoptosis via AKT/Bcl-2/Bax in colon cancer cells. J Cell Mol Med 22:131-140 (2018). PubMed: 28816021
- Gao J et al. CD155 downregulation synergizes with adriamycin to induce breast cancer cell apoptosis. Apoptosis 23:512-520 (2018). PubMed: 30039180