Anti-Poliovirus Receptor/PVR antibody (ab103630)
Key features and details
- Rabbit polyclonal to Poliovirus Receptor/PVR
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
Overview
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Product name
Anti-Poliovirus Receptor/PVR antibody
See all Poliovirus Receptor/PVR primary antibodies -
Description
Rabbit polyclonal to Poliovirus Receptor/PVR -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Mouse, Human -
Immunogen
Full length protein corresponding to Human Poliovirus Receptor/PVR aa 1-417.
Database link: NP_006496.2 -
General notes
This product was previously labelled as Poliovirus Receptor
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.4
Constituent: 2.68% PBS -
Concentration information loading... -
Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
Our Abpromise guarantee covers the use of ab103630 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB | 1/500 - 1/1000. Predicted molecular weight: 45 kDa. |
Target
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Function
Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport. -
Sequence similarities
Belongs to the nectin family.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
Cellular localization
Secreted and Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 5817 Human
- Entrez Gene: 52118 Mouse
- Omim: 173850 Human
- SwissProt: P15151 Human
- SwissProt: Q91WP1 Mouse
- Unigene: 171844 Human
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Alternative names
- CD155 antibody
- CD155 antigen antibody
- FLJ25946 antibody
see all
Images
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Western blot - Anti-Poliovirus Receptor/PVR antibody (ab103630)Anti-Poliovirus Receptor/PVR antibody (ab103630) at 1/500 dilution + Mouse stomach tissue lysate at 50 µg
Predicted band size: 45 kDa -
Western blot - Anti-Poliovirus Receptor/PVR antibody (ab103630)All lanes : Anti-Poliovirus Receptor/PVR antibody (ab103630) at 1/500 dilution
Lane 1 : Poliovirus Receptor/PVR transfected 293T cell lysate
Lane 2 : Non-transfected 293T cell lysate
Lysates/proteins at 25 µg per lane.
Predicted band size: 45 kDa
Protocols
Datasheets and documents
References (3)
ab103630 has been referenced in 3 publications.
- Zheng Q et al. CD155 contributes to the mesenchymal phenotype of triple-negative breast cancer. Cancer Sci 111:383-394 (2020). PubMed: 31830330
- Zheng Q et al. CD155 knockdown promotes apoptosis via AKT/Bcl-2/Bax in colon cancer cells. J Cell Mol Med 22:131-140 (2018). PubMed: 28816021
- Gao J et al. CD155 downregulation synergizes with adriamycin to induce breast cancer cell apoptosis. Apoptosis 23:512-520 (2018). PubMed: 30039180
