Product nameAnti-Poliovirus Receptor/PVR antibody
See all Poliovirus Receptor/PVR primary antibodies
DescriptionRabbit polyclonal to Poliovirus Receptor/PVR
Tested applicationsSuitable for: WB, IHC-Pmore details
Species reactivityReacts with: Mouse, Human
Recombinant fragment corresponding to Human Poliovirus Receptor/PVR aa 220-345. NP_006496.4
Database link: P15151
- WB: SW620, HT-29, SKOV3, HepG2 and HeLa whole cell lysate; mouse brain and liver tissue lysate. IHC-P: Human prostate and heart tissue.
This product was previously labelled as Poliovirus Receptor
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.3
Preservative: 0.02% Sodium azide
Concentration information loading...
PurityProtein A purified
- HeLa whole cell lysate (ab150035)
- Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
- HepG2 whole cell lysate (ab166833)
- Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
- Mouse liver tissue lysate - total protein (ab29301)
- HeLa whole cell lysate (ab29545)
- Mouse brain tissue lysate - total protein (ab30151)
- HT29 whole cell lysate (ab3952)
- Mouse brain tissue lysate - total protein (ab4022)
- HepG2 whole cell lysate (ab7900)
Our Abpromise guarantee covers the use of ab230338 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/2000. Predicted molecular weight: 45 kDa.|
|IHC-P||1/200. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.|
FunctionMediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.
Sequence similaritiesBelongs to the nectin family.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Cellular localizationSecreted and Cell membrane.
- Information by UniProt
- CD155 antibody
- CD155 antigen antibody
- FLJ25946 antibody
All lanes : Anti-Poliovirus Receptor/PVR antibody (ab230338) at 1/500 dilution
Lane 1 : SW620 whole cell lysate
Lane 2 : HT-29 (human colorectal adenocarcinoma cell line) whole cell lysate
Lane 3 : H460 whole cell lysate
Lane 4 : SKOV3 whole cell lysate
Lane 5 : HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate
Lane 6 : HepG2 (human liver hepatocellular carcinoma cell line) whole cell lysate
Lane 7 : HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate
Lane 8 : Mouse brain tissue lysate
Lane 9 : Mouse liver tissue lysate
Predicted band size: 45 kDa
Paraffin-embedded, formalin-fixed human prostate tissue stained for Poliovirus Receptor/PVR using ab230338 at 1/200 dilution in immunohistochemical analysis.
Paraffin-embedded, formalin-fixed human heart tissue stained for Poliovirus Receptor/PVR using ab230338 at 1/200 dilution in immunohistochemical analysis.
ab230338 has not yet been referenced specifically in any publications.