Overview

  • Product name

  • Description

    Rabbit polyclonal to POLR3G
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human POLR3G aa 178-223. The exact sequence is proprietary.
    Sequence:

    DDDDAAEQEEYDEEEQEEENDYINSYFEDGDDFGADSDDNMDEATY


    Database link: O15318

  • Positive control

    • MCF7, RAW 264.7 and H9C2 whole cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab200721 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 26 kDa.

Target

  • Function

    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.
  • Sequence similarities

    Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • DNA directed RNA polymerase III 32 kDa polypeptide antibody
    • DNA-directed RNA polymerase III subunit G antibody
    • DNA-directed RNA polymerase III subunit RPC7 antibody
    • Polr3g antibody
    • Polymerase (RNA) III (DNA directed) polypeptide G (32kD) antibody
    • RNA polymerase III 32 kDa subunit antibody
    • RNA polymerase III subunit C7 antibody
    • RPC32 antibody
    • RPC7 antibody
    • RPC7_HUMAN antibody
    see all

Images

  • All lanes : Anti-POLR3G antibody (ab200721)

    Lane 1 : MCF7 whole cell lysate
    Lane 2 : RAW 264.7 whole cell lysate
    Lane 3 : H9C2 whole cell lysate

    Predicted band size: 26 kDa

References

ab200721 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab200721.
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