Overview

  • Product name

    Anti-Polycystin 1/PC1 antibody
    See all Polycystin 1/PC1 primary antibodies
  • Description

    Goat polyclonal to Polycystin 1/PC1
  • Host species

    Goat
  • Specificity

    ab118354 is expected to recognize both reported isoforms (NP_001009944.2; NP_000287.3).
  • Tested applications

    Suitable for: PepArrmore details
    Unsuitable for: WB
  • Species reactivity


    Predicted to work with: Mouse, Rat, Horse, Dog, Human, Pig
  • Immunogen

    Synthetic peptide corresponding to Human Polycystin 1/PC1 aa 2281-2292 (Cysteine residue). (NP_001009944.2; NP_000287.3)
    Sequence:

    KSYDPNLEDGDQT

  • General notes

     This product was previously labelled as Polycystin 1

     

Properties

Applications

Our Abpromise guarantee covers the use of ab118354 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
PepArr 1/1000.
  • Application notes
    Is unsuitable for WB.
  • Target

    • Function

      May be an ion-channel regulator. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Involved in adhesive protein-protein and protein-carbohydrate interactions.
    • Involvement in disease

      Defects in PKD1 are the cause of polycystic kidney disease autosomal dominant type 1 (ADPKD1) [MIM:173900]. ADPKD is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. Its prevalence is estimated at about 1/1000.
    • Sequence similarities

      Belongs to the polycystin family.
      Contains 1 C-type lectin domain.
      Contains 1 GPS domain.
      Contains 1 LDL-receptor class A domain.
      Contains 2 LRR (leucine-rich) repeats.
      Contains 1 LRRCT domain.
      Contains 1 LRRNT domain.
      Contains 17 PKD domains.
      Contains 1 PLAT domain.
      Contains 1 REJ domain.
      Contains 1 WSC domain.
    • Domain

      The LDL-receptor class A domain is atypical; the potential calcium-binding site is missing.
    • Cellular localization

      Membrane.
    • Information by UniProt
    • Database links

    • Alternative names

      • Autosomal dominant polycystic kidney disease 1 protein antibody
      • Autosomal dominant polycystic kidney disease protein 1 antibody
      • nPKC-D1 antibody
      • nPKC-mu antibody
      • OTTHUMP00000208669 antibody
      • OTTHUMP00000208670 antibody
      • PBP antibody
      • Pc-1 antibody
      • PKD antibody
      • Pkd1 antibody
      • PKD1_HUMAN antibody
      • Polycystic Kidney Disease 1 antibody
      • polycystic kidney disease-associated protein antibody
      • Polycystin 1 Precursor antibody
      • Polycystin-1 antibody
      • Protein kinase C mu type antibody
      • Protein kinase D antibody
      • Serine/threonine-protein kinase D1 antibody
      • transient receptor potential cation channel, subfamily P, member 1 antibody
      • TRPP1 antibody
      see all

    References

    ab118354 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    Answer

    Thank you for contacting us.

    Yes, the a.a. region from 2281 - 2292 isn't really C-terminal, it's more internal. I have since removed that note from the online datasheet, but it will take a few days to refresh. Thank you for pointing that out.

    You may be interested in our ab72473, which corresponds to the 6th cytoplasmic loop of human polycystin 1, which according to Swiss Prot a.a is 4107 - 4303.

    https://www.abcam.com/Polycystin-1-antibody-ab72473.html

    I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

    Free Rabbit monoclonal antibody with any purchase of a primary antibody, while stocks last! Quote “RABMAB-XBSMG” in your next primary antibody order. For more information, visit the following link: https://www.abcam.com/index.html?pageconfig=resource&rid=15447

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