Overview

  • Product name

    Anti-Polycystin 1/PC1 antibody - C-terminal
    See all Polycystin 1/PC1 primary antibodies
  • Description

    Goat polyclonal to Polycystin 1/PC1 - C-terminal
  • Host species

    Goat
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human Polycystin 1/PC1 aa 4289-4300 (C terminal) (Cysteine residue). NP_001009944.1; NP_000287.2.
    Sequence:

    C-RTPLRAKNKVHP


    Database link: P98161

  • Positive control

    • IHC-P: Human kidney tissue.
  • General notes

     This product was previously labelled as Polycystin 1

     

Properties

Applications

Our Abpromise guarantee covers the use of ab223673 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 3 - 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    May be an ion-channel regulator. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Involved in adhesive protein-protein and protein-carbohydrate interactions.
  • Involvement in disease

    Defects in PKD1 are the cause of polycystic kidney disease autosomal dominant type 1 (ADPKD1) [MIM:173900]. ADPKD is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. Its prevalence is estimated at about 1/1000.
  • Sequence similarities

    Belongs to the polycystin family.
    Contains 1 C-type lectin domain.
    Contains 1 GPS domain.
    Contains 1 LDL-receptor class A domain.
    Contains 2 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
    Contains 1 LRRNT domain.
    Contains 17 PKD domains.
    Contains 1 PLAT domain.
    Contains 1 REJ domain.
    Contains 1 WSC domain.
  • Domain

    The LDL-receptor class A domain is atypical; the potential calcium-binding site is missing.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Autosomal dominant polycystic kidney disease 1 protein antibody
    • Autosomal dominant polycystic kidney disease protein 1 antibody
    • nPKC-D1 antibody
    • nPKC-mu antibody
    • OTTHUMP00000208669 antibody
    • OTTHUMP00000208670 antibody
    • PBP antibody
    • Pc-1 antibody
    • PKD antibody
    • Pkd1 antibody
    • PKD1_HUMAN antibody
    • Polycystic Kidney Disease 1 antibody
    • polycystic kidney disease-associated protein antibody
    • Polycystin 1 Precursor antibody
    • Polycystin-1 antibody
    • Protein kinase C mu type antibody
    • Protein kinase D antibody
    • Serine/threonine-protein kinase D1 antibody
    • transient receptor potential cation channel, subfamily P, member 1 antibody
    • TRPP1 antibody
    see all

Images

  • ab223673 (3.75µg/ml) staining of paraffin embedded Human spleen. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
  • Paraffin-embedded human kidney tissue stained for Polycystin 1/PC1 using ab223673 at 3.8 µg/ml in immunohistochemical analysis. AP staining.

References

ab223673 has not yet been referenced specifically in any publications.

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