Overview

  • Product name

    Polydatin, Anti-inflammatory
  • Description

    Anti-inflammatory
  • Biological description

    Inhibits LPS induced ICAM1 and NF-kB. Resveratrol precursor and Dihydroresveratrol (Asc 2862) derivative. Anti-inflammatory, anti-ischemic, neuroprotective and antiseptic effects in vivo.
  • Purity

    > 97%
  • CAS Number

    27208-80-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2S,3R,4S,5S,6R)-2-[3-Hydroxy-5-[(E)-2-(4-hydroxyphenyl)ethenyl]phenoxy]-6-
    (hydroxymethyl)oxane-3,4,5-triol

  • Molecular weight

    390.38
  • Molecular formula

    C20H22O8
  • PubChem identifier

    5281718
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO and in water

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC(=CC=C1C=CC2=CC(=CC(=C2)OC3C(C(C(C(O3)CO)O)O)O)O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Ravagnan G  et al. Polydatin, a natural precursor of resveratrol, induces ß-defensin production and reduces inflammatory response. Inflammation 36:26-34 (2013). Read more (PubMed: 22956122) »
  • Wang X  et al. Polydatin--a new mitochondria protector for acute severe hemorrhagic shock treatment. Expert Opin Investig Drugs 22:169-79 (2013). Read more (PubMed: 23241098) »
  • Li XH  et al. Protective effects of polydatin on septic lung injury in mice via upregulation of HO-1. Mediators Inflamm 2013:354087 (2013). Read more (PubMed: 23431240) »
  • Wu MJ  et al. Polydatin protects against lipopolysaccharide-induced fulminant hepatic failure in D-galactosamine-sensitized mice. Int J Immunopathol Pharmacol 25:923-34 (0). Read more (PubMed: 23298483) »

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