Anti-Polymeric immunoglobulin receptor/PIGR antibody (ab188814)

Overview

  • Product name

    Anti-Polymeric immunoglobulin receptor/PIGR antibody
    See all Polymeric immunoglobulin receptor/PIGR primary antibodies
  • Description

    Rabbit polyclonal to Polymeric immunoglobulin receptor/PIGR
  • Host species

    Rabbit
  • Specificity

    BLAST analysis of the peptide immunogen showed no homology with other human proteins.
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Monkey, Gorilla, Common marmoset, Orangutan
  • Immunogen

    Synthetic peptide corresponding to Human Polymeric immunoglobulin receptor/PIGR. Synthetic 18 amino acid peptide from cytoplasmic domain.
    Database link: P01833

  • Positive control

    • Human small intestine, human kidney tissue.
  • General notes

    Previously labelled as PIGR. 

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.1% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab188814 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 - 7.5 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function

    This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
  • Sequence similarities

    Contains 5 Ig-like V-type (immunoglobulin-like) domains.
  • Post-translational
    modifications

    N-glycosylation is not necessary for Ig binding.
  • Cellular localization

    Secreted and Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Hepatocellular carcinoma associated protein TB6 antibody
    • Hepatocellular carcinoma-associated protein TB6 antibody
    • MGC125361 antibody
    • MGC125362 antibody
    • Phosphatidylinositol glycan, class R antibody
    • PIGR antibody
    • PIGR_HUMAN antibody
    • Poly Ig receptor antibody
    • Poly-Ig receptor antibody
    • Polymeric immunoglobulin receptor antibody
    • Secretory component antibody
    • Transmembrane secretory component antibody
    see all

Images

  • Immunohistochemical analysis of formalin fixed paraffin embedded human kidney tissue labeling Polymeric immunoglobulin receptor/PIGR with ab188814 at 7.5 µg/ml

  • Immunohistochemical analysis of formalin fixed paraffin embedded human small intestine tissue labeling Polymeric immunoglobulin receptor/PIGR with ab188814 at 7.5 µg/ml

References

ab188814 has not yet been referenced specifically in any publications.

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