Overview

  • Product name

    Ponasterone A, Ecdysone analog
  • Description

    Ecdysone analog. Potent ecdysteroid activity inducer.
  • Biological description

    Ecdysone (ab142425) analog. Potent ecdysteroid activity inducer (EC50 = 70 nM). Increases β-galactosidase expression levels similar to Muristerone A (ab144309). Induces ecdysone-inducible mammalian expression system in vivo.
  • Purity

    > 95%
  • CAS Number

    13408-56-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2S,3R,5R,9R,10R,13R,14S,17S)-17-[(2R,3R)-2,3-Dihydroxy-6-methylheptan-2-yl]-2,3,14-trihydroxy-10,13-dimethyl-2,3,4,5,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-6-one
  • Molecular weight

    464.63
  • Molecular formula

    C27H44O6
  • PubChem identifier

    115127
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol and in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C)CC[C@H]([C@@](C)([C@H]1CC[C@@]2([C@@]1(CC[C@H]3C2=CC(=O)[C@H]4[C@@]3(C[C@@H]([C@@H](C4)O)O)C)C)O)O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Ren B  et al. Unprecedented conformational flexibility revealed in the ligand-binding domains of the Bovicola ovis ecdysone receptor (EcR) and ultraspiracle (USP) subunits. Acta Crystallogr D Biol Crystallogr 70:1954-64 (2014). Read more (PubMed: 25004972) »
  • Xiao YY  et al. Development of a ponasterone A-inducible gene expression system for application in cultured skeletal muscle cells. Int J Biochem Cell Biol 35:79-85 (2003). Read more (PubMed: 12467649) »
  • Constantino S  et al. The ecdysone inducible gene expression system: unexpected effects of muristerone A and ponasterone A on cytokine signaling in mammalian cells. Eur Cytokine Netw 12:365-7 (0). Read more (PubMed: 11399528) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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