Ponesimod, sphingosine-1-phophate receptor agonist (ab231509)

Overview

  • Product name

    Ponesimod, sphingosine-1-phophate receptor agonist
  • Description

    Potent sphingosine-1-phophate receptor agonist
  • Biological description

    Ponesimod is a potent agonist of sphingosine-1-phophate receptor. (S1P1/EDG-1; IC50s = 6, >10,000, 2,068, 1,956, and 142 nM for S1P1-S1P5, respectively, in a radioligand binding assay). Selectively activates S1P1 in a GTPγS assay (EC50s = 5.7, >10,000, 105, 1,108, and 59.1 nM, for S1P1-S1P5, respectively).

  • CAS Number

    854107-55-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (5Z)-5-[[3-Chloro-4-[(2R)-2,3-dihydroxypropoxy]phenyl]methylidene]-3-(2-methylphenyl)-2-propylimino-1,3-thiazolidin-4-one

  • Molecular weight

    460.97
  • Molecular formula

    C23H25ClN2O4S
  • PubChem identifier

    11363176
  • Storage instructions

    Shipped at 4°C. Store at -20°C.
  • Solubility overview

    Soluble in DMSO to 10 mM.

  • SMILES

    CCCN=C1N(C(=O)/C(=C/C2=CC(=C(C=C2)OC[C@@H](CO)O)Cl)/S1)C3=CC=CC=C3C
  • Source

    Synthetic

References

This product has been referenced in:

  • Bolli MH  et al. 2-imino-thiazolidin-4-one derivatives as potent, orally active S1P1 receptor agonists. J Med Chem 53:4198-211 (2010). Read more (PubMed: 20446681) »

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