Product nameAnti-PORCN/PPN antibody
See all PORCN/PPN primary antibodies
DescriptionRabbit polyclonal to PORCN/PPN
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse
Full length protein corresponding to Human PORCN/PPN aa 1-450. (NP_073736.2).
MATFSRQEFFQQLLQGCLLPTAQQGLDQIWLLLAICLACRLLWRLGLPSY LKHASTVAGGFFSLYHFFQLHMVWVVLLSLLCYLVLFLCRHSSHRGVFLS VTILIYLLMGEMHMVDTVTWHKMRGAQMIVAMKAVSLGFDLDRGEVGTVP SPVEFMGYLYFVGTIVFGPWISFHSYLQAVQGRPLSCRWLQKVARSLALA LLCLVLSTCVGPYLFPYFIPLNGDRLLRKWLRAYESAVSFHFSNYFVGFL SEATATLAGAGFTEEKDHLEWDLTVSKPLNVELPRSMVEVVTSWNLPMSY WLNNYVFKNALRLGTFSAVLVTYAASALLHGFSFHLAAVLLSLAFITYVE HVLRKRLARILSACVLSKRCPPDCSHQHRLGLGVRALNLLFGALAIFHLA YLGSLFDVDVDDTTEEQGYGMAYTVHKWSELSWASHWVTFGCWIFYRLIG
Database link: Q9H237-4
- PORCN/PPN transfected 293T cell line lysate.
This product was previously labelled as PORCN
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.20
Constituent: 100% PBS
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab172664 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 1 µg/ml. Predicted molecular weight: 51 kDa.|
FunctionModulates the processing of Wnt proteins. Probable protein-cysteine N-palmitoyltransferase that palmitoylates Wnt family members.
Tissue specificityIsoform 1 is expressed in fetal brain, brain, amygdala, caudate nucleus, cerebellum, hippocampus, pituitary, thalamus, heart, skeletal muscle and testis. Isoform 4 is expressed in amygdala, corpus callosum, hippocampus, spinal cord, kidney, liver, lung, spleen, uterus, testis. Isoform 2 and isoform 3 are expressed in substantia negra, spinal cord, heart and lung.
Involvement in diseaseDefects in PORCN are the cause of focal dermal hypoplasia (FODH) [MIM:305600]; also known as Goltz Gorlin syndrome. A rare congenital ectomesodermal disorder characterized by a combination of skin defects, skeletal abnormalities, and ocular anomalies. Affected individuals have patchy dermal hypoplasia, often in a distribution pattern following the Blaschko lines, and areas of subcutaneous fat herniation or deposition of fat into the dermis. In addition, sparse and brittle hair, hypoplastic nails and papillomas have been described. Skeletal abnormalities usually comprise syndactyly, ectrodactyly, and brachydactyly, and in some cases osteopathia striata has been seen. Patients frequently have ocular anomalies, including microphthalmia/ anophthalmia, coloboma, pigmentary and vascularization defects of the retina. Dental abnormalities are often present.
Sequence similaritiesBelongs to the membrane-bound acyltransferase family. Porcupine subfamily.
Cellular localizationEndoplasmic reticulum membrane.
- Information by UniProt
FormCellular component Endoplasmic reticulum, Membrane. Modulates the processing of Wnt proteins. Probable protein-cysteine N-palmitoyltransferase that palmitoylates Wnt family members.
- DHOF antibody
- FODH antibody
- MG61 antibody
All lanes : Anti-PORCN/PPN antibody (ab172664) at 1 µg/ml
Lane 1 : PORCN/PPN transfected 293T cell line lysate
Lane 2 : Non-transfected 293T cell line lysate
Lysates/proteins at 15 µl per lane.
All lanes : Goat anti-Rabbit IgG (H+L) HRP at 1/7500 dilution
Developed using the ECL technique.
Predicted band size: 51 kDa
ab172664 has not yet been referenced specifically in any publications.