Overview

  • Product name

    PPADS, P2 purinergic receptor antagonist
  • Description

    P2 purinergic receptor antagonist
  • Biological description

    P2 purinergic receptor antagonist.
  • CAS Number

    149017-66-3
  • Chemical structure

    Chemical Structure

Properties

Images

  • Inhibition by suramin and PPADS significantly reduces the ATP-induced increase in extracellular H+ flux from isolated Müller cells.
    Mean responses to 10 µM ATP with or without suramin and PPADS in the bath; N = 7, error bars represent SEMs.

  • Astrocyte Ca2+ signal inhibition does not affect interictal discharges. (A–D) Mean percentage of astrocytes activated by the ictal discharges (A), mean duration (B) and frequency (C) of the ictal discharge, and mean frequency of interictal discharges (D) under different experimental conditions in EC slice preparations. Controls (n=16), MPEP (ab120008) (n=7), PPADS (ab120009) (n=9), and MPEP+PPADS (n=3). A single asterisk (*) indicates p<0.05; double asterisks (**), p<0.01.
  • Ca2+ signal from a field A neuron, a field B neuron, and field A astrocytes in response to repetitive episodes of NMDA stimulation (black arrowheads). The NMDA stimulation that evoked an ictal discharge became ineffective after blocking the astrocyte response by bath perfusion with MPEP (ab120008) and PPADS (ab120009). An ictal discharge could be recovered by increasing the number of NMDA puffs (white arrowheads). A double NMDA pulse evoked both astrocyte activation and the ictal discharge after inhibitor washout.

References

This product has been referenced in:

  • Lin Y  et al. P2 receptor antagonist PPADS confers neuroprotection against glutamate/NMDA toxicity. Neurosci Lett 377:97-100 (2005). Read more (PubMed: 15740844) »
  • von Kügelgen I & Wetter A Molecular pharmacology of P2Y-receptors. Naunyn Schmiedebergs Arch Pharmacol 362:310-23 (2000). Read more (PubMed: 11111826) »
  • Lambrecht G Agonists and antagonists acting at P2X receptors: selectivity profiles and functional implications. Naunyn Schmiedebergs Arch Pharmacol 362:340-50 (2000). Read more (PubMed: 11111828) »
See all 7 Publications for this product

Customer reviews and Q&As

1-4 of 4 Abreviews or Q&A

Answer


J’ai informé abcamBiochemicals pour voir si on pourrait ajouter une note sur la fiche technique comme quoi il faut vérifier le CoA des biochemicals avant l’achat d’un lot pour savoir le poids moléculaire exact.
La prochaine fois que vous commandez, je vous conseille de regarder les CoA de tous les lots que nous avons en stock et de spécifier sur votre commande quel lot vous aimeriez recevoir.

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Question
Answer

Pour ce genre de produit, le poids moléculaire va changer de lot à lot dû au niveau d’hydration. Pour tous nos « Biochemicals » nous avons donc téléchargés le certificat d’analyse (CoA)) de chaque lot sur notre site web.

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Question
Answer


J’ai contacté le laboratoire qui m’a confirmé que pour le lot que vous avez reçu, le poids moléculaire est bien 743.42. Ceci est parce que la molécule est hydratée et contient 8 molécules d’eau, donc la formule devient C14H10N3Na4O12PS2.8H2O.

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Answer

Please find the CoA attached.

I hope this is helpful. Please contact me again if you have any further questions.

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