Overview

  • Product name

  • Description

    Rabbit polyclonal to PPAP2A
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide corresponding to Human PPAP2A (internal sequence). (NP_003702).
    Database link: O14494

  • Positive control

    • Human liver cancer tissue lysate; Human breast cancer tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab198280 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/25 - 1/100.
WB 1/500 - 1/2000. Predicted molecular weight: 32 kDa.

Target

  • Function

    Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. It's down-regulation may contribute to the development of colon adenocarcinoma.
  • Tissue specificity

    Ubiquitously expressed with highest expression found in prostate. Isoform 1 is predominant in kidney, lung, placenta and liver. Isoform 2 is predominant in heart and pancreas. Found to be down-regulated in colon adenocarcinomas.
  • Sequence similarities

    Belongs to the PA-phosphatase related phosphoesterase family.
  • Post-translational
    modifications

    N-glycosylated. Contains high-mannose oligosaccharides.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Lipid phosphate phosphohydrolase 1 antibody
    • Lipid phosphate phosphohydrolase 1a antibody
    • LLP1a antibody
    • LPP1 antibody
    • LPP1_HUMAN antibody
    • PAP 2a antibody
    • PAP-2a antibody
    • PAP2 antibody
    • PAP2-alpha antibody
    • PAP2a antibody
    • PAP2a2 antibody
    • PAP2alpha2 antibody
    • PAPalpha1 antibody
    • Phosphatidate phosphohydrolase type 2a antibody
    • Phosphatidic acid phosphatase 2a antibody
    • Phosphatidic acid phosphatase type 2A antibody
    • Phosphatidic acid phosphohydrolase type 2a antibody
    • PPAP2A antibody
    • Type 2 phosphatidic acid phosphatase alpha antibody
    • Type 2 phosphatidic acid phosphohydrolase antibody
    see all

Images

  • Anti-PPAP2A antibody (ab198280) at 1/650 dilution + Human liver cancer tissue lysate at 30 µg

    Predicted band size: 32 kDa


    Exposure time: 1 second


    10% SDS-PAGE

  • Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue labeling PPAP2A with ab198280 at 1/40 dilution.

References

This product has been referenced in:

  • Hu Q  et al. Lipid profile of platelets and platelet-derived microparticles in ovarian cancer. BBA Clin 6:76-81 (2016). WB ; Human . Read more (PubMed: 27453821) »
See 1 Publication for this product

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