Overview

  • Product name

    Anti-PPAR alpha antibody [1331CT894.186.143]
    See all PPAR alpha primary antibodies
  • Description

    Mouse monoclonal [1331CT894.186.143] to PPAR alpha
  • Host species

    Mouse
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    Recombinant fragment corresponding to Human PPAR alpha.
    Database link: Q07869

  • Positive control

    • HeLa, Jurkat and NIH/3T3 cell line lysates.

Applications

Our Abpromise guarantee covers the use of ab191226 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 52 kDa.

Target

  • Function

    Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.
  • Tissue specificity

    Skeletal muscle, liver, heart and kidney.
  • Sequence similarities

    Belongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • hPPAR antibody
    • MGC2237 antibody
    • MGC2452 antibody
    • NR1C1 antibody
    • Nuclear receptor subfamily 1 group C member 1 antibody
    • OTTHUMP00000197740 antibody
    • OTTHUMP00000197741 antibody
    • Peroxisome proliferative activated receptor alpha antibody
    • Peroxisome proliferator activated receptor alpha antibody
    • Peroxisome proliferator-activated receptor alpha antibody
    • PPAR antibody
    • PPAR-alpha antibody
    • ppara antibody
    • PPARA_HUMAN antibody
    • PPARalpha antibody
    see all

Images

  • All lanes : Anti-PPAR alpha antibody [1331CT894.186.143] (ab191226) at 1/1000 dilution

    Lane 1 : HeLa cell line lysate
    Lane 2 : Jurkat cell line lysate
    Lane 3 : NIH/3T3 cell line lysate

    Lysates/proteins at 35 µg per lane.

    Secondary
    All lanes : Goat anti-mouse IgG H&L(HRP) at 1/5000 dilution

    Predicted band size: 52 kDa

References

This product has been referenced in:

  • Yan FJ  et al. ZNF300 stimulates fatty acid oxidation and alleviates hepatosteatosis through regulating PPARa. Biochem J N/A:N/A (2018). Read more (PubMed: 30568000) »
See 1 Publication for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab191226.
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