Key features and details
- Mouse polyclonal to PPP1R3B
- Suitable for: WB
- Reacts with: Rat, Human
- Isotype: IgG
Product nameAnti-PPP1R3B antibody
See all PPP1R3B primary antibodies
DescriptionMouse polyclonal to PPP1R3B
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Rat, Human
Full length Human protein (AAH43388.1)
- Rat brain lysate
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferpH: 7.4
Constituent: 2.68% PBS
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab89105 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 1 µg/ml. Predicted molecular weight: 33 kDa.|
FunctionActs as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes.
Tissue specificityHighly expressed in liver. Expressed moderately in skeletal muscle and myotubes (at protein level). Expressed predominantly in heart and skeletal muscle. Expressed moderately in liver. Expressed weakly in placenta, lung and kidney.
Sequence similaritiesContains 1 CBM21 (carbohydrate binding type-21) domain.
DomainThe N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to PYGL.
- Information by UniProt
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ab89105 has not yet been referenced specifically in any publications.