• Product name

  • Description

    Goat polyclonal to PPP2R4
  • Host species

  • Specificity

    This antibody is expected to recognize all reported isoforms (NP_821068.1; NP_066954.2; NP_821070.1).
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
    Predicted to work with: Rabbit, Cow, Dog, Orangutan
  • Immunogen

    Synthetic peptide:


    , corresponding to C terminal amino acids 312-323 of Human PPP2R4 (NP_066954.2).

  • Positive control

    • Human, mouse or rat Liver lysate and HepG2 cell lysate.


  • Form

  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer

    pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 0.5% BSA, 0.5% Tris buffered saline
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Purification notes

    ab87673 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • Clonality

  • Isotype

  • Research areas


Our Abpromise guarantee covers the use of ab87673 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 37 kDa (predicted molecular weight: 37 kDa).
IHC-P Use a concentration of 3.75 µg/ml.


  • Function

    PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activty of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A.
  • Tissue specificity

    Widely expressed.
  • Sequence similarities

    Belongs to the PTPA-type PPIase family.
  • Cellular localization

    Cytoplasm. Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • subunit B'' antibody
    • KIAA0044 antibody
    • MGC2184 antibody
    • Phosphotyrosyl phosphatase activator antibody
    • PP2A antibody
    • PP2A phosphatase activator antibody
    • PP2A subunit B' antibody
    • PP2A subunit B' isoform PR53 antibody
    • PP2A subunit B' PR53 isoform antibody
    • PPP2R4 antibody
    • PR53 antibody
    • PR53 isoform antibody
    • Protein phosphatase 2, regulatory subunit B-prime antibody
    • Protein phosphatase 2A activator regulatory subunit 4 antibody
    • Protein phosphatase 2A regulatory subunit B' (PR 53) antibody
    • PTPA antibody
    • PTPA_HUMAN antibody
    • Serine/threonine protein phosphatase 2A regulatory subunit B' antibody
    • Serine/threonine-protein phosphatase 2A activator antibody
    • Serine/threonine-protein phosphatase 2A regulatory subunit 4 antibody
    • Serine/threonine-protein phosphatase 2A regulatory subunit B'' antibody
    see all


  • Ab87673 (3.75µg/ml) staining of paraffin embedded Human Testis. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
  • All lanes : Anti-PPP2R4 antibody (ab87673) at 0.5 µg/ml

    Lane 1 : Human Liver lysate in RIPA buffer
    Lane 2 : Mouse Liver lysate in RIPA buffer
    Lane 3 : Rat Liver lysate in RIPA buffer

    Lysates/proteins at 35 µg per lane.

    Developed using the ECL technique.

    Predicted band size: 37 kDa
    Observed band size: 37 kDa


ab87673 has not yet been referenced specifically in any publications.

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