Overview

  • Product name

    PR 619, DUB inhibitor
  • Description

    Cell-permeable, non-selective and reversible DUB inhibitor
  • Biological description

    Cell-permeable, non-selective and reversible DUB inhibitor (IC50 values are 5 to 20 μM). Induces polyubiquitinated protein accumulation in cells without directly affecting proteasome activity. Activates autophagy.
  • Purity

    > 99%
  • CAS Number

    2645-32-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Thiocyanic acid 2,6-diamino-3,5-pyridinediyl ester
  • Molecular weight

    223.27
  • Molecular formula

    C7H5N5S2
  • PubChem identifier

    2817763
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=C(C(=NC(=C1SC#N)N)N)SC#N
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Seiberlich V  et al. Inhibition of protein deubiquitination by PR-619 activates the autophagic pathway in OLN-t40 oligodendroglial cells. Cell Biochem Biophys 67:149-60 (2013). Read more (PubMed: 23686611) »
  • Udeshi ND  et al. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. Mol Cell Proteomics 11:148-59 (2012). Read more (PubMed: 22505724) »
  • Seiberlich V  et al. The small molecule inhibitor PR-619 of deubiquitinating enzymes affects the microtubule network and causes protein aggregate formation in neural cells: implications for neurodegenerative diseases. Biochim Biophys Acta 1823:2057-68 (2012). Read more (PubMed: 22565157) »
See 1 Publication for this product

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