Anti-HELZ2 antibody (ab129781)
Key features and details
- Rabbit polyclonal to HELZ2
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-HELZ2 antibody -
Description
Rabbit polyclonal to HELZ2 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide corresponding to Human HELZ2 (internal sequence).
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Positive control
- Extracts from Jurkat cells
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
Storage buffer
pH: 7
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 49% PBS
PBS is without Mg2+ and Ca2+ -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
ab129781 was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab129781 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/1000. Predicted molecular weight: 295 kDa.
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Notes |
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WB
1/500 - 1/1000. Predicted molecular weight: 295 kDa. |
Target
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Function
Helicase that acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA. -
Tissue specificity
Expressed in various tissues including heart, pancreas, skeletal muscle, colon, spleen, liver, kidney, lung, peripheral blood and placenta. -
Sequence similarities
Belongs to the DNA2/NAM7 helicase family.
Contains 1 C2H2-type zinc finger. -
Domain
Contains 5 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. These motifs are not required for interaction with PPARG. -
Cellular localization
Nucleus. - Information by UniProt
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Database links
- Entrez Gene: 85441 Human
- Omim: 611265 Human
- SwissProt: Q9BYK8 Human
- Unigene: 517180 Human
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Alternative names
- ATP-dependent helicase PRIC285 antibody
- KIAA1769 antibody
- PDIP1 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (3)
ab129781 has been referenced in 3 publications.
- Luqman-Fatah A et al. The interferon stimulated gene-encoded protein HELZ2 inhibits human LINE-1 retrotransposition and LINE-1 RNA-mediated type I interferon induction. Nat Commun 14:203 (2023). PubMed: 36639706
- Thulasi Raman SN et al. Dysregulation of Ephrin receptor and PPAR signaling pathways in neural progenitor cells infected by Zika virus. Emerg Microbes Infect 9:2046-2060 (2020). PubMed: 32873194
- Fusco DN et al. HELZ2 Is an IFN Effector Mediating Suppression of Dengue Virus. Front Microbiol 8:240 (2017). PubMed: 28265266