Pramipexole dihydrochloride, Dopamine D2-like receptor agonist. D3-preferring. (ab120569)

Overview

  • Product name

    Pramipexole dihydrochloride, Dopamine D2-like receptor agonist. D3-preferring.
  • Description

    Dopamine D2-like receptor agonist. D3-preferring.
  • Biological description

    Dopamine D2-like receptor agonist showing some selectivity for D3 (Ki values are 3.9 (D2L), 3.3 (D2S), 0.5 (D3) and 3.9 nM (D4)). Potent antioxidant. Displays antidepressant and anti-Parkinsonian effects.
  • Purity

    > 99%
  • CAS Number

    104632-25-9
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Newman-Tancredi A  et al. Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. II. Agonist and antagonist properties at subtypes of dopamine D(2)-like receptor and alpha(1)/alpha(2)-adrenoceptor. J Pharmacol Exp Ther 303:805-14 (2002). Read more (PubMed: 12388667) »
  • Ling ZD  et al. Both the antioxidant and D3 agonist actions of pramipexole mediate its neuroprotective actions in mesencephalic cultures. J Pharmacol Exp Ther 289:202-10 (1999). Read more (PubMed: 10087005) »
  • Mierau J  et al. Pramipexole binding and activation of cloned and expressed dopamine D2, D3 and D4 receptors. Eur J Pharmacol 290:29-36 (1995). Read more (PubMed: 7664822) »

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