Pravastatin Sodium Salt, HMG-CoA reductase inhibitor (ab142617)

Overview

  • Product name

    Pravastatin Sodium Salt, HMG-CoA reductase inhibitor
  • Description

    Potent, competitive HMG-CoA reductase inhibitor
  • Biological description

    Potent, competitive HMG-CoA reductase inhibitor (IC50 = 95 nM). Biologically active metabolite of mevastatin (ab120652). Immunomodulator and cardiotropic agent. Active in vivo and in vitro. Water-soluble.
  • Purity

    > 98%
  • CAS Number

    81131-70-6
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Narisawa T  et al. Chemoprevention by pravastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, of N-methyl-N-nitrosourea-induced colon carcinogenesis in F344 rats. Jpn J Cancer Res 87:798-804 (1996). Read more (PubMed: 8797885) »
  • Cohen LH  et al. Pravastatin inhibited the cholesterol synthesis in human hepatoma cell line Hep G2 less than simvastatin and lovastatin, which is reflected in the upregulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and squalene synthase. Biochem Pharmacol 45:2203-8 (1993). Read more (PubMed: 8517861) »
  • Koga T  et al. Tissue-selective inhibition of cholesterol synthesis in vivo by pravastatin sodium, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor. Biochim Biophys Acta 1045:115-20 (1990). Read more (PubMed: 2116173) »

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