Anti-PRAX-1 antibody (ab121856)
Key features and details
- Rabbit polyclonal to PRAX-1
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-PRAX-1 antibody -
Description
Rabbit polyclonal to PRAX-1 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
antigen sequence: RTASTSTLGE KDPGPAAPSL AKQEAEWTAG EACPASSSTQ GARAQQAPNT EMCQGGDPGS GLRPRAEKED TAELGVHLVN SLVDHGRNSD LSD, corresponding to internal sequence amino acids 1167-1259 of Human PRAX-1.
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Positive control
- Human esophagus tissue.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab121856 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
1/20 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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Notes |
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IHC-P
1/20 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target
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Tissue specificity
Predominantly expressed in brain, pituitary gland and thymus in adults. In adult brain, highest expression found in temporal lobe and the putamen, followed by amygdala, caudate nucleus, cerebral cortex, occipital and frontal lobe. A high expression level is also observed in fetal tissues like brain, heart, kidney and thymus. -
Sequence similarities
Belongs to the RIMBP family.
Contains 3 fibronectin type-III domains.
Contains 3 SH3 domains. -
Domain
The SH3 and proline-rich domain is required for the interaction with BZRP and the second SH3 domain mediates binding to a proline-rich motif in RIMS1 and RIMS2. -
Cellular localization
Cytoplasm. Mitochondrion. Preferentially expressed in the mitochondria in the presence of BZRP. - Information by UniProt
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Database links
- Entrez Gene: 9256 Human
- Omim: 610764 Human
- SwissProt: O95153 Human
- Unigene: 112499 Human
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Alternative names
- Bzrap1 antibody
- D230016K05 antibody
- mKIAA0612 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab121856 has been referenced in 1 publication.
- Liu D et al. microRNA-155 Modulates Hepatic Stellate Cell Proliferation, Apoptosis, and Cell Cycle Progression in Rats With Alcoholic Hepatitis via the MAPK Signaling Pathway Through Targeting SOCS1. Front Pharmacol 11:270 (2020). PubMed: 32317960