Overview

  • Product name

  • Description

    Rabbit polyclonal to PRD
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: IP
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Giant Panda
  • Immunogen

    Synthetic peptide within Human PRD aa 443-493. The exact sequence is proprietary.
    Database link: P12955

  • Positive control

    • WB: HeLa, HEK-293T and Jurkat whole cell lysates.
  • General notes

     This product was previously labelled as PEPD

     

Properties

Applications

Our Abpromise guarantee covers the use of ab226414 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/2000 - 1/10000. Predicted molecular weight: 55 kDa.
  • Application notes
    Is unsuitable for IP.
  • Target

    • Function

      Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because the high level of iminoacids in collagen.
    • Involvement in disease

      Defects in PEPD are a cause of prolidase deficiency (PD) [MIM:170100]. Prolidase deficiency is an autosomal recessive disorder associated with iminodipeptiduria. The clinical phenotype includes skin ulcers, mental retardation, recurrent infections, and a characteristic facies. These features, however are incompletely penetrant and highly variable in both age of onset and severity. There is a tight linkage between the polymorphisms of prolidase and the myotonic dystrophy trait.
    • Sequence similarities

      Belongs to the peptidase M24B family. Eukaryotic-type prolidase subfamily.
    • Information by UniProt
    • Database links

    • Alternative names

      • Aminoacyl L proline hydrolase antibody
      • Imidodipeptidase antibody
      • MGC10905 antibody
      • MGC95081 antibody
      • Pep 4 antibody
      • Pep4 antibody
      • pepD antibody
      • PEPD_HUMAN antibody
      • Peptidase 4 antibody
      • Peptidase D antibody
      • Prolidase antibody
      • Proline dipeptidase antibody
      • X pro dipeptidase antibody
      • X-Pro dipeptidase antibody
      • Xaa-Pro dipeptidase antibody
      see all

    Images

    • All lanes : Anti-PRD antibody (ab226414) at 0.1 µg/ml

      Lane 1 : HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate
      Lane 2 : HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate
      Lane 3 : Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate

      Lysates/proteins at 50 µg per lane.

      Developed using the ECL technique.

      Predicted band size: 55 kDa


      Exposure time: 3 minutes


      Cell lysates were prepared using NETN lysis buffer.

    References

    ab226414 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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