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    prdc-antibody-c-terminal-ab228736.pdf

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Signal Transduction Cytoskeleton / ECM Extracellular Matrix Structures Bone
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Anti-PRDC antibody - C-terminal (ab228736)

  • Datasheet
  • SDS
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Western blot - Anti-PRDC antibody - C-terminal (ab228736)
  • Western blot - Anti-PRDC antibody - C-terminal (ab228736)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PRDC antibody - C-terminal (ab228736)

Key features and details

  • Rabbit polyclonal to PRDC - C-terminal
  • Suitable for: WB, IHC-P
  • Reacts with: Human
  • Isotype: IgG

You may also be interested in

Protein
Product image
Recombinant Human PRDC protein (ab163828)
Secondary
Product image
Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

View more associated products

Overview

  • Product name

    Anti-PRDC antibody - C-terminal
    See all PRDC primary antibodies
  • Description

    Rabbit polyclonal to PRDC - C-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rhesus monkey
  • Immunogen

    Synthetic peptide within Human PRDC (C terminal). The exact sequence is proprietary. Carrier-protein conjugated.
    Database link: Q9H772

  • Positive control

    • WB: A549 and IMR32 whole cell extracts. IHC-P: Human placenta tissue.
  • General notes

     This product was previously labelled as GREM2

     

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine)
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Signal Transduction
    • Cytoskeleton / ECM
    • Extracellular Matrix
    • Structures
    • Bone
    • Stem Cells
    • Embryonic Stem Cells
    • Cytokines

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
  • Positive Controls

    • A549 whole cell lysate (ab7910)
  • Recombinant Protein

    • Recombinant Human PRDC protein (ab163828)
  • Related Products

    • Recombinant Human PRDC protein (denatured) (ab156347)
    • Recombinant Human PRDC protein (ab163828)

Applications

Our Abpromise guarantee covers the use of ab228736 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 19 kDa.
IHC-P 1/100 - 1/1000.

Target

  • Function

    Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner. Antagonized BMP4-induced suppression of progesterone production in granulosa cells.
  • Sequence similarities

    Belongs to the DAN family.
    Contains 1 CTCK (C-terminal cystine knot-like) domain.
  • Cellular localization

    Secreted.
  • Target information above from: UniProt accession Q9H772 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 64388 Human
    • Entrez Gene: 23893 Mouse
    • Entrez Gene: 289264 Rat
    • Entrez Gene: 708280 Rhesus monkey
    • Omim: 608832 Human
    • SwissProt: Q9H772 Human
    • SwissProt: O88273 Mouse
    • Unigene: 98206 Human
    • Unigene: 25760 Mouse
    • Unigene: 16419 Rat
    see all
  • Alternative names

    • BMP antagonist 2 antibody
    • CKTSF1B2 antibody
    • Cysteine knot superfamily 1 antibody
    • Cysteine knot superfamily 1 BMP antagonist 2 antibody
    • DAN domain family member 3 antibody
    • DAND 3 antibody
    • DAND3 antibody
    • GREM 2 antibody
    • Grem2 antibody
    • GREM2_HUMAN antibody
    • Gremlin 2 antibody
    • Gremlin 2 cysteine knot superfamily homolog antibody
    • Gremlin-2 antibody
    • Gremlin2 antibody
    • PRDC antibody
    • Protein related to DAN and cerberus antibody
    see all

Images

  • Western blot - Anti-PRDC antibody - C-terminal (ab228736)
    Western blot - Anti-PRDC antibody - C-terminal (ab228736)
    Anti-PRDC antibody - C-terminal (ab228736) at 1/500 dilution + A549 (human lung carcinoma cell line) whole cell extract at 30 µg

    Predicted band size: 19 kDa



    15% SDS-PAGE gel.

  • Western blot - Anti-PRDC antibody - C-terminal (ab228736)
    Western blot - Anti-PRDC antibody - C-terminal (ab228736)
    Anti-PRDC antibody - C-terminal (ab228736) at 1/500 dilution + IMR32 whole cell extract at 30 µg

    Predicted band size: 19 kDa



    15% SDS-PAGE gel.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PRDC antibody - C-terminal (ab228736)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PRDC antibody - C-terminal (ab228736)

    Paraffin-embedded human placenta tissue stained for PRDC using ab228736 at 1/100 dilution in immunohistochemical analysis.

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

    • Datasheet
    • SDS
  • References (0)

    Publishing research using ab228736? Please let us know so that we can cite the reference in this datasheet.

    ab228736 has not yet been referenced specifically in any publications.

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