Overview

  • Product name

  • Description

    Rabbit Polyclonal to PRDM16
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide within Human PRDM16 aa 771-804 (internal sequence) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: Q9HAZ2

  • Positive control

    • WB: LNCaP cell line lysate and mouse lung tissue lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab202344 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 140 kDa.

Target

  • Function

    Binds DNA and functions as a transcriptional regulator. Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism. Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells. Functions also as a repressor of TGF-beta signaling. Isoform 4 may regulate granulocytes differentiation.
  • Tissue specificity

    Expressed in uterus and kidney.
  • Involvement in disease

    Note=A chromosomal aberration involving PRDM16 is found in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Reciprocal translocation t(1;3)(p36;q21). Isoform 4 is specifically expressed in adult T-cell leukemia.
  • Sequence similarities

    Contains 10 C2H2-type zinc fingers.
    Contains 1 SET domain.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • CMD1LL antibody
    • KIAA1675 antibody
    • LVNC8 antibody
    • MDS1/EVI1 like gene 1 antibody
    • MDS1/EVI1-like gene 1 antibody
    • MEL1 antibody
    • PFM 13 antibody
    • PFM13 antibody
    • PR domain containing 16 antibody
    • PR domain containing protein 16 antibody
    • PR domain zinc finger protein 16 antibody
    • PR domain-containing protein 16 antibody
    • PRD16_HUMAN antibody
    • Prdm16 antibody
    • Transcription factor MEL 1 antibody
    • Transcription factor MEL1 antibody
    see all

Images

  • All lanes : Anti-PRDM16 antibody (ab202344) at 1/1000 dilution

    Lane 1 : LNCaP cell line lysate
    Lane 2 : Mouse lung tissue lysate

    Lysates/proteins at 35 µg per lane.

    Secondary
    All lanes : Goat anti-rabbit IgG H&L(HRP) at 1/10000 dilution

    Predicted band size: 140 kDa

References

ab202344 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab202344.
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